Experimental distraction osteogenesis of the rabbit mandible

no effect of local insulin like growth factor-1 infusion

K Stewart, S White, G. O. Lvoff, F Bonar, W Walsh, M. Poole

Research output: Chapter in Book/Report/Conference proceedingConference proceeding contribution

Abstract

The rabbit model has been used to study the effects of local infusion of IGF-1 upon bone deposition during a mandibular distraction osteogenesis. Rabbits were studied in 5 groups. All rabbits except sham operated controls underwent distraction to 15mm. The variables studied were the rate of distraction (0.5mm b.d. versus 1.5mm b.d.) and local IGF-1 infusion via osmotic infusion pumps. Analysis by DEXA scanning and three point bending at 28 days post distraction demonstrated no difference in density or strength of bone between the experimental groups bar the controls. Histological examination demonstrated non-union across the distraction gap to be more common in rapidly distracted rabbits. IGF-1 infusion did not appear to affect the prevalence of non-union. It is concluded that infusion of exogenous IGF-1 does not augment bone healing during distraction and that union is best insured by a rate of distraction of 1mm per day.

Original languageEnglish
Title of host publicationINTERNATIONAL CONGRESS ON CRANIAL AND FACIAL BONE DISTRACTION PROCESSES
EditorsPA Diner, MP Vazquez
PublisherMEDIMOND S R L
Pages21-24
Number of pages4
ISBN (Print)88-323-0619-0
Publication statusPublished - 1997
EventInternational Congress on Cranial and Facial Bone Distraction Processes - PARIS, France
Duration: 19 Jun 199721 Jun 1997

Conference

ConferenceInternational Congress on Cranial and Facial Bone Distraction Processes
CountryFrance
CityPARIS
Period19/06/9721/06/97

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