Experimental models to investigate the function of dendritic cell subsets

Challenges and implications

D. G. Hancock, T. V. Guy, E. Shklovskaya, B. Fazekas de St Groth*

*Corresponding author for this work

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The dendritic cell (DC) lineage is remarkably heterogeneous. It has been postulated that specialized DC subsets have evolved in order to select and support the multitude of possible T cell differentiation pathways. However, defining the function of individual DC subsets has proven remarkably difficult, and DC subset control of key T cell fates such as tolerance, T helper cell commitment and regulatory T cell induction is still not well understood. While the difficulty in assigning unique functions to particular DC subsets may be due to sharing of functions, it may also reflect a lack of appropriate physiological in-vivo models for studying DC function. In this paper we review the limitations associated with many of the current DC models and highlight some of the underlying difficulties involved in studying the function of murine DC subsets.

Original languageEnglish
Pages (from-to)147-154
Number of pages8
JournalClinical and Experimental Immunology
Volume171
Issue number2
DOIs
Publication statusPublished - Feb 2013
Externally publishedYes

Keywords

  • animal models/studies - mice/rats
  • Antibody engineering
  • Dendritic cells (myeloid
  • Monocyte-derived)
  • Plasmacytoid
  • T cells
  • Transgenics/knock-outs

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