Expert consensus on the use of on-demand treatments for OFF episodes in Parkinson's disease: a modified Delphi panel

Stuart H. Isaacson; Madhureeta Achari; Roongroj Bhidayasiri; Cynthia Comella; Jill Giordano Farmer; Fiona Gupta; Sarah Jones; David Kreitzman; Daniel Kremens; Simon J. G. Lewis; Werner Poewe; Eduardo Tolosa; Cynthia Campos; Sarah N. Gibbs; Michael S. Broder

doi:10.1002/mdc3.13690

Expert consensus on the use of on-demand treatments for OFF episodes in Parkinson's disease: a modified Delphi panel

Stuart H. Isaacson, Madhureeta Achari, Roongroj Bhidayasiri, Cynthia Comella, Jill Giordano Farmer, Fiona Gupta, Sarah Jones, David Kreitzman, Daniel Kremens, Simon J. G. Lewis, Werner Poewe, Eduardo Tolosa, Cynthia Campos, Sarah N. Gibbs, Michael S. Broder^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

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Abstract

Background: On-demand treatments can treat OFF episodes in Parkinson's disease, however, there is limited information regarding when to prescribe them. Objective: Develop expert consensus to determine appropriate clinical factors for considering on-demand treatments. Methods: Using a RAND/UCLA modified Delphi panel method, a panel developed consensus on the use of on-demand treatments for OFF episodes. Results: The panel agreed on-demand treatments were appropriate when OFF episodes were associated with greater functional impact and interfered with basic daily activities. The panel also agreed on-demand treatment may be appropriate for patients with morning akinesia and/or delayed ON of first levodopa dose and >1 type of OFF episode (eg, early morning OFF or wearing OFF regardless of frequency). Conclusions: Experts agreed on-demand treatment is appropriate for many patients with OFF episodes. The greater the functional impact of OFF episodes, the more likely experts agreed that on-demand treatment is appropriate to prescribe.

Original language	English
Pages (from-to)	652-657
Number of pages	6
Journal	Movement Disorders Clinical Practice
Volume	10
Issue number	4
DOIs	https://doi.org/10.1002/mdc3.13690
Publication status	Published - Apr 2023
Externally published	Yes

Bibliographical note

Copyright Sunovion Pharmaceuticals Inc. 2023. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

movement disorderneurology
OFF episode
on-demand treatment
Parkinson's disease

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10.1002/mdc3.13690Licence: CC BY-NC-ND

Publisher version (open access)Final published version, 211 KBLicence: CC BY-NC-ND

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Isaacson, S. H., Achari, M., Bhidayasiri, R., Comella, C., Farmer, J. G., Gupta, F., Jones, S., Kreitzman, D., Kremens, D., Lewis, S. J. G., Poewe, W., Tolosa, E., Campos, C., Gibbs, S. N., & Broder, M. S. (2023). Expert consensus on the use of on-demand treatments for OFF episodes in Parkinson's disease: a modified Delphi panel. Movement Disorders Clinical Practice, 10(4), 652-657. https://doi.org/10.1002/mdc3.13690

@article{20132997f0b34ad8a8a5239408793654,

title = "Expert consensus on the use of on-demand treatments for OFF episodes in Parkinson's disease: a modified Delphi panel",

abstract = "Background: On-demand treatments can treat OFF episodes in Parkinson's disease, however, there is limited information regarding when to prescribe them. Objective: Develop expert consensus to determine appropriate clinical factors for considering on-demand treatments. Methods: Using a RAND/UCLA modified Delphi panel method, a panel developed consensus on the use of on-demand treatments for OFF episodes. Results: The panel agreed on-demand treatments were appropriate when OFF episodes were associated with greater functional impact and interfered with basic daily activities. The panel also agreed on-demand treatment may be appropriate for patients with morning akinesia and/or delayed ON of first levodopa dose and >1 type of OFF episode (eg, early morning OFF or wearing OFF regardless of frequency). Conclusions: Experts agreed on-demand treatment is appropriate for many patients with OFF episodes. The greater the functional impact of OFF episodes, the more likely experts agreed that on-demand treatment is appropriate to prescribe.",

keywords = "movement disorderneurology, OFF episode, on-demand treatment, Parkinson's disease",

author = "Isaacson, \{Stuart H.\} and Madhureeta Achari and Roongroj Bhidayasiri and Cynthia Comella and Farmer, \{Jill Giordano\} and Fiona Gupta and Sarah Jones and David Kreitzman and Daniel Kremens and Lewis, \{Simon J. G.\} and Werner Poewe and Eduardo Tolosa and Cynthia Campos and Gibbs, \{Sarah N.\} and Broder, \{Michael S.\}",

note = "Copyright Sunovion Pharmaceuticals Inc. 2023. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.",

year = "2023",

month = apr,

doi = "10.1002/mdc3.13690",

language = "English",

volume = "10",

pages = "652--657",

journal = "Movement Disorders Clinical Practice",

issn = "2330-1619",

publisher = "John Wiley \& Sons",

number = "4",

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Isaacson, SH, Achari, M, Bhidayasiri, R, Comella, C, Farmer, JG, Gupta, F, Jones, S, Kreitzman, D, Kremens, D, Lewis, SJG, Poewe, W, Tolosa, E, Campos, C, Gibbs, SN & Broder, MS 2023, 'Expert consensus on the use of on-demand treatments for OFF episodes in Parkinson's disease: a modified Delphi panel', Movement Disorders Clinical Practice, vol. 10, no. 4, pp. 652-657. https://doi.org/10.1002/mdc3.13690

TY - JOUR

T1 - Expert consensus on the use of on-demand treatments for OFF episodes in Parkinson's disease

T2 - a modified Delphi panel

AU - Isaacson, Stuart H.

AU - Achari, Madhureeta

AU - Bhidayasiri, Roongroj

AU - Comella, Cynthia

AU - Farmer, Jill Giordano

AU - Gupta, Fiona

AU - Jones, Sarah

AU - Kreitzman, David

AU - Kremens, Daniel

AU - Lewis, Simon J. G.

AU - Poewe, Werner

AU - Tolosa, Eduardo

AU - Campos, Cynthia

AU - Gibbs, Sarah N.

AU - Broder, Michael S.

N1 - Copyright Sunovion Pharmaceuticals Inc. 2023. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

PY - 2023/4

Y1 - 2023/4

N2 - Background: On-demand treatments can treat OFF episodes in Parkinson's disease, however, there is limited information regarding when to prescribe them. Objective: Develop expert consensus to determine appropriate clinical factors for considering on-demand treatments. Methods: Using a RAND/UCLA modified Delphi panel method, a panel developed consensus on the use of on-demand treatments for OFF episodes. Results: The panel agreed on-demand treatments were appropriate when OFF episodes were associated with greater functional impact and interfered with basic daily activities. The panel also agreed on-demand treatment may be appropriate for patients with morning akinesia and/or delayed ON of first levodopa dose and >1 type of OFF episode (eg, early morning OFF or wearing OFF regardless of frequency). Conclusions: Experts agreed on-demand treatment is appropriate for many patients with OFF episodes. The greater the functional impact of OFF episodes, the more likely experts agreed that on-demand treatment is appropriate to prescribe.

AB - Background: On-demand treatments can treat OFF episodes in Parkinson's disease, however, there is limited information regarding when to prescribe them. Objective: Develop expert consensus to determine appropriate clinical factors for considering on-demand treatments. Methods: Using a RAND/UCLA modified Delphi panel method, a panel developed consensus on the use of on-demand treatments for OFF episodes. Results: The panel agreed on-demand treatments were appropriate when OFF episodes were associated with greater functional impact and interfered with basic daily activities. The panel also agreed on-demand treatment may be appropriate for patients with morning akinesia and/or delayed ON of first levodopa dose and >1 type of OFF episode (eg, early morning OFF or wearing OFF regardless of frequency). Conclusions: Experts agreed on-demand treatment is appropriate for many patients with OFF episodes. The greater the functional impact of OFF episodes, the more likely experts agreed that on-demand treatment is appropriate to prescribe.

KW - movement disorderneurology

KW - OFF episode

KW - on-demand treatment

KW - Parkinson's disease

UR - https://www.scopus.com/pages/publications/85150623216

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DO - 10.1002/mdc3.13690

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AN - SCOPUS:85150623216

SN - 2330-1619

VL - 10

SP - 652

EP - 657

JO - Movement Disorders Clinical Practice

JF - Movement Disorders Clinical Practice

IS - 4

ER -

Expert consensus on the use of on-demand treatments for OFF episodes in Parkinson's disease: a modified Delphi panel

Abstract

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Keywords

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