Exploring the K isotope composition of Göttingen minipig brain regions, and implications for Alzheimer's disease

Brandon Mahan*, Theo Tacail, Jamie Lewis, Tim Elliott, Mette Habekost, Simon Turner, Roger Chung, Frédéric Moynier

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)
16 Downloads (Pure)

Abstract

Natural stable metal isotopes have shown utility in differentiation between healthy and diseased brain states (e.g. Alzheimer's disease, AD). While the AD brain accumulates some metals, it purges others, namely K (accompanied by increased serum K, suggesting brain-blood transferal). Here, K isotope compositions of Göttingen minipig brain regions for two AD models at midlife are reported. Results indicate heavy K isotope enrichment where amyloid beta (Aβ) accumulation is observed, and this enrichment correlates with relative K depletion. These results suggest preferential efflux of isotopically light K+ from the brain, a linkage between brain K concentrations and isotope compositions, and linkage to Aβ (previously shown to purge cellular brain K+). Brain K isotope compositions differ from that for serum and brain K is much more abundant than in serum, suggesting that changes in brain K may transfer a measurable K isotope excursion to serum, thereby generating an early AD biomarker.

Original languageEnglish
Article numbermfac090
Pages (from-to)1-13
Number of pages13
JournalMetallomics
Volume14
Issue number12
DOIs
Publication statusPublished - 8 Dec 2022

Bibliographical note

© The Author(s) 2022.Published by Oxford University Press. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

  • Alzheimer's disease
  • brain potassium
  • isotope geochemistry
  • isotope metallomics
  • neurodegeneration
  • porcine model
  • Alzheimer's disease, brain potassium
  • neurodegeneration, porcine model

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