Expression of c-fos protein in the medulla oblongata of conscious rabbits in response to baroreceptor activation

Yu Wen Li*, R. A L Dampney

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

71 Citations (Scopus)

Abstract

Neuronal expression of c-fos protein (Fos) in the medulla in response to baroreceptor activation was studied in conscious rabbits. Raising arterial pressure resulted in a marked increase, compared to control animals, in Fos immunoreactivity in the nucleus tractus solitarius, area postrema and ventrolateral medulla (VLM). Fos-immunoreactive neurons in the VLM extended from the level just rostral to the obex to 3 mm more caudal. Only a small proportion of these neurons showed tyrosine hydroxylase immunoreactivity. The results indicate that baroreceptor activation induces Fos expression in circumscribed medullary regions which have previously been shown to receive excitatory baroreceptor inputs.

Original languageEnglish
Pages (from-to)70-74
Number of pages5
JournalNeuroscience Letters
Volume144
Issue number1-2
DOIs
Publication statusPublished - 14 Sep 1992
Externally publishedYes

Keywords

  • Area postrema
  • Arterial pressure
  • Baroreceptor reflex
  • Nucleus tractus solitarii
  • Proto-oncogene
  • Tyrosine hydroxylase
  • Ventrolateral medulla

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