Extinction of a cocaine-taking context that protects against drug-primed reinstatement is dependent on the metabotropic glutamate 5 receptor

Jee Hyun Kim, Christina Perry, Sophia Luikinga, Isabel Zbukvic, Robyn M. Brown, Andrew J. Lawrence*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

We investigated the effects of extinguishing action-reward versus context-reward associations on drug-primed reinstatement, and the potential role of the metabotropic glutamate 5 receptor (mGlu5) in these different types of extinction in rats that self-administer cocaine. We observed that daily context extinction (non-reinforced exposures to the cocaine-taking context with retracted levers) was just as effective as daily lever extinction in reducing cocaine-primed reinstatement compared with passive abstinence. Additionally, systemic injections of the mGlu5 negative allosteric modulator MTEP (3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]-pyridine) following each extinction session significantly impaired the ability of context extinction to reduce cocaine-primed reinstatement, without affecting reinstatement after lever extinction or passive abstinence.

Original languageEnglish
Pages (from-to)482-489
Number of pages8
JournalAddiction Biology
Volume20
Issue number3
DOIs
Publication statusPublished - May 2015
Externally publishedYes

Keywords

  • abstinence
  • addiction
  • context
  • extinction
  • mGlu5
  • MTEP

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