Extraprostatic extension (EPE) of prostatic carcinoma: Is its proximity to the surgical margin or Gleason score important?

Ruta Gupta, Rachel O'Connell, Anne Maree Haynes, Phillip D. Stricker, Wade Barrett, Jennifer J. Turner, Warick Delprado, Lisa G. Horvath, James G. Kench*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    6 Citations (Scopus)

    Abstract

    Objective To examine the association between histopathological factors of extraprostatic prostate cancer and outcome. Patients and Methods Patients with extraprostatic extension (EPE) without positive margins, seminal vesicle or lymph node involvement were analysed from a consecutive radical prostatectomy cohort of 1136 (2002-2006) for: (i) distance of EPE from the margin; (ii) Gleason score of the EPE; and (iii) extent of EPE. Log-rank, Kaplan-Meier, and Cox regression analyses were performed. Results The study included 194 pT3a, pN0, R0 patients with a median follow-up of 5.4 years, with 37 (19%) patients experiencing biochemical relapse (BCR). On univariable analysis, patients with a Gleason score of ≥8 in the extraprostatic portion showed increased incidence of BCR compared with those with Gleason scores of ≤7 (P = 0.03). The proximity of the EPE to the margin (0.01-7.5 mm) did not correlate with BCR. On multivariable analysis, the extent of EPE, the Gleason score of the dominant nodule or of the EPE portion did not correlate with BCR. Conclusion Data from this study using current International Society of Urological Pathology Gleason scoring and EPE criteria indicate that close proximity of EPE to the margin is not associated with recurrence. Gleason score ≥8 within EPE is associated with an increased BCR risk on univariable analysis, but larger studies are required to confirm whether extensive Gleason pattern 4 in an EPE indicates increased risk in an otherwise overall Gleason score 7 cancer.

    Original languageEnglish
    Pages (from-to)343-350
    Number of pages8
    JournalBJU international
    Volume116
    Issue number3
    DOIs
    Publication statusPublished - 1 Sep 2015

    Keywords

    • prostate
    • prostatic adenocarcinoma
    • radical prostatectomy
    • extraprostatic extension
    • margins
    • Gleason scores

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