Fabrication and characterization of a multiwall carbon nanotube needle biosensor

Yeo Heung Yun; Adam Bange; Vesselin N. Shanov; William R. Heineman; H. Brian Halsall; Zhongyun Dong; Abdul Jazieh; Yi Tu; Danny Wong; Sarah Pixley; Michael Behbehani; Mark J. Schulz

Fabrication and characterization of a multiwall carbon nanotube needle biosensor

Yeo Heung Yun^*, Adam Bange, Vesselin N. Shanov, William R. Heineman, H. Brian Halsall, Zhongyun Dong, Abdul Jazieh, Yi Tu, Danny Wong, Sarah Pixley, Michael Behbehani, Mark J. Schulz

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference proceeding contribution › peer-review

2 Citations (Scopus)

18 Downloads (Pure)

Abstract

A nanotube electronic needle biosensor was developed to provide fast, low cost, accurate detection of biomolecules. The sensor was formed by synthesizing highly aligned multi-wall carbon nanotube arrays. Nanotube bundles from the array were welded onto the tips of tungsten needles using a microscope. The needles were then encased in glass and a polymer coating. Cyclic voltammetry (CV) for the respective reduction of 6 mM K₃Fe(CN)₆ in a 1.0 M KNO₃ was performed to examine the redox behavior of the nanotube needle. The CV results showed a steady-state response attributable to radial diffusion with a high steady-state current density. An amperometric sensor was then developed for glucose detection by physical attachment of glucose oxidase on the nanotube needle. A label-free immunosensor based on electrochemical impedance spectroscopy was also formed. The nanotube needle amperometric have good sensitivity with a low detection limit, and the possibility exists to keep decreasing the size of the needle to increase the sensitivity.

Original language	English
Title of host publication	2006 6th IEEE Conference on Nanotechnology, IEEE-NANO 2006
Place of Publication	Piscataway, NJ
Publisher	Institute of Electrical and Electronics Engineers (IEEE)
Pages	280-283
Number of pages	4
Volume	1
ISBN (Print)	1424400783, 9781424400782
Publication status	Published - 2006
Event	2006 6th IEEE Conference on Nanotechnology, IEEE-NANO 2006 - Cincinnati, OH, United States Duration: 17 Jun 2006 → 20 Jun 2006

Other

Other	2006 6th IEEE Conference on Nanotechnology, IEEE-NANO 2006
Country/Territory	United States
City	Cincinnati, OH
Period	17/06/06 → 20/06/06

Bibliographical note

Copyright 2006 IEEE. Reprinted from 2006 Sixth Conference on Nanotechnology : Westin Hotel, Cincinnati, Ohio, USA, 17-20 July, 2006. This material is posted here with permission of the IEEE. Such permission of the IEEE does not in any way imply IEEE endorsement of any of Macquarie Universityâ€™s products or services. Internal or personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution must be obtained from the IEEE by writing to pubs-permissions@ieee.org. By choosing to view this document, you agree to all provisions of the copyright laws protecting it.

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Yun, Y. H., Bange, A., Shanov, V. N., Heineman, W. R., Brian Halsall, H., Dong, Z., Jazieh, A., Tu, Y., Wong, D., Pixley, S., Behbehani, M., & Schulz, M. J. (2006). Fabrication and characterization of a multiwall carbon nanotube needle biosensor. In 2006 6th IEEE Conference on Nanotechnology, IEEE-NANO 2006 (Vol. 1, pp. 280-283). [1717079] Institute of Electrical and Electronics Engineers (IEEE).

@inproceedings{b00df8c7ceda48449fda591ae671cf18,

title = "Fabrication and characterization of a multiwall carbon nanotube needle biosensor",

abstract = "A nanotube electronic needle biosensor was developed to provide fast, low cost, accurate detection of biomolecules. The sensor was formed by synthesizing highly aligned multi-wall carbon nanotube arrays. Nanotube bundles from the array were welded onto the tips of tungsten needles using a microscope. The needles were then encased in glass and a polymer coating. Cyclic voltammetry (CV) for the respective reduction of 6 mM K3Fe(CN)6 in a 1.0 M KNO3 was performed to examine the redox behavior of the nanotube needle. The CV results showed a steady-state response attributable to radial diffusion with a high steady-state current density. An amperometric sensor was then developed for glucose detection by physical attachment of glucose oxidase on the nanotube needle. A label-free immunosensor based on electrochemical impedance spectroscopy was also formed. The nanotube needle amperometric have good sensitivity with a low detection limit, and the possibility exists to keep decreasing the size of the needle to increase the sensitivity.",

author = "Yun, {Yeo Heung} and Adam Bange and Shanov, {Vesselin N.} and Heineman, {William R.} and {Brian Halsall}, H. and Zhongyun Dong and Abdul Jazieh and Yi Tu and Danny Wong and Sarah Pixley and Michael Behbehani and Schulz, {Mark J.}",

note = "Copyright 2006 IEEE. Reprinted from 2006 Sixth Conference on Nanotechnology : Westin Hotel, Cincinnati, Ohio, USA, 17-20 July, 2006. This material is posted here with permission of the IEEE. Such permission of the IEEE does not in any way imply IEEE endorsement of any of Macquarie University{\^a}€{\texttrademark}s products or services. Internal or personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution must be obtained from the IEEE by writing to pubs-permissions@ieee.org. By choosing to view this document, you agree to all provisions of the copyright laws protecting it.; 2006 6th IEEE Conference on Nanotechnology, IEEE-NANO 2006 ; Conference date: 17-06-2006 Through 20-06-2006",

year = "2006",

language = "English",

isbn = "1424400783",

volume = "1",

pages = "280--283",

booktitle = "2006 6th IEEE Conference on Nanotechnology, IEEE-NANO 2006",

publisher = "Institute of Electrical and Electronics Engineers (IEEE)",

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Yun, YH, Bange, A, Shanov, VN, Heineman, WR, Brian Halsall, H, Dong, Z, Jazieh, A, Tu, Y, Wong, D, Pixley, S, Behbehani, M & Schulz, MJ 2006, Fabrication and characterization of a multiwall carbon nanotube needle biosensor. in 2006 6th IEEE Conference on Nanotechnology, IEEE-NANO 2006. vol. 1, 1717079, Institute of Electrical and Electronics Engineers (IEEE), Piscataway, NJ, pp. 280-283, 2006 6th IEEE Conference on Nanotechnology, IEEE-NANO 2006, Cincinnati, OH, United States, 17/06/06.

Fabrication and characterization of a multiwall carbon nanotube needle biosensor. / Yun, Yeo Heung; Bange, Adam; Shanov, Vesselin N. et al.
2006 6th IEEE Conference on Nanotechnology, IEEE-NANO 2006. Vol. 1 Piscataway, NJ: Institute of Electrical and Electronics Engineers (IEEE), 2006. p. 280-283 1717079.

Research output: Chapter in Book/Report/Conference proceeding › Conference proceeding contribution › peer-review

TY - GEN

T1 - Fabrication and characterization of a multiwall carbon nanotube needle biosensor

AU - Yun, Yeo Heung

AU - Bange, Adam

AU - Shanov, Vesselin N.

AU - Heineman, William R.

AU - Brian Halsall, H.

AU - Dong, Zhongyun

AU - Jazieh, Abdul

AU - Tu, Yi

AU - Wong, Danny

AU - Pixley, Sarah

AU - Behbehani, Michael

AU - Schulz, Mark J.

N1 - Copyright 2006 IEEE. Reprinted from 2006 Sixth Conference on Nanotechnology : Westin Hotel, Cincinnati, Ohio, USA, 17-20 July, 2006. This material is posted here with permission of the IEEE. Such permission of the IEEE does not in any way imply IEEE endorsement of any of Macquarie Universityâ€™s products or services. Internal or personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution must be obtained from the IEEE by writing to pubs-permissions@ieee.org. By choosing to view this document, you agree to all provisions of the copyright laws protecting it.

PY - 2006

Y1 - 2006

N2 - A nanotube electronic needle biosensor was developed to provide fast, low cost, accurate detection of biomolecules. The sensor was formed by synthesizing highly aligned multi-wall carbon nanotube arrays. Nanotube bundles from the array were welded onto the tips of tungsten needles using a microscope. The needles were then encased in glass and a polymer coating. Cyclic voltammetry (CV) for the respective reduction of 6 mM K3Fe(CN)6 in a 1.0 M KNO3 was performed to examine the redox behavior of the nanotube needle. The CV results showed a steady-state response attributable to radial diffusion with a high steady-state current density. An amperometric sensor was then developed for glucose detection by physical attachment of glucose oxidase on the nanotube needle. A label-free immunosensor based on electrochemical impedance spectroscopy was also formed. The nanotube needle amperometric have good sensitivity with a low detection limit, and the possibility exists to keep decreasing the size of the needle to increase the sensitivity.

AB - A nanotube electronic needle biosensor was developed to provide fast, low cost, accurate detection of biomolecules. The sensor was formed by synthesizing highly aligned multi-wall carbon nanotube arrays. Nanotube bundles from the array were welded onto the tips of tungsten needles using a microscope. The needles were then encased in glass and a polymer coating. Cyclic voltammetry (CV) for the respective reduction of 6 mM K3Fe(CN)6 in a 1.0 M KNO3 was performed to examine the redox behavior of the nanotube needle. The CV results showed a steady-state response attributable to radial diffusion with a high steady-state current density. An amperometric sensor was then developed for glucose detection by physical attachment of glucose oxidase on the nanotube needle. A label-free immunosensor based on electrochemical impedance spectroscopy was also formed. The nanotube needle amperometric have good sensitivity with a low detection limit, and the possibility exists to keep decreasing the size of the needle to increase the sensitivity.

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M3 - Conference proceeding contribution

AN - SCOPUS:42549139788

SN - 1424400783

SN - 9781424400782

VL - 1

SP - 280

EP - 283

BT - 2006 6th IEEE Conference on Nanotechnology, IEEE-NANO 2006

PB - Institute of Electrical and Electronics Engineers (IEEE)

CY - Piscataway, NJ

T2 - 2006 6th IEEE Conference on Nanotechnology, IEEE-NANO 2006

Y2 - 17 June 2006 through 20 June 2006

ER -

Fabrication and characterization of a multiwall carbon nanotube needle biosensor

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