Facial emotional processing in HIV infection: relation to neurocognitive and neuropsychiatric status

Tammy A. Lane, Danielle M. Moore, Jennifer Batchelor, Bruce J. Brew, Lucette A. Cysique

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Objective: To examine facial emotional processing in HIV+ individuals and its relation to neurocognitive performance, neuropsychiatric symptomatology and immune status. Method: Participants included 85 HIV+ individuals (83 males, 2 females) and 25 age-comparable HIV- individuals (22 males, 3 females). Participants underwent The University of Pennsylvania computerized neuropsychological facial emotion test battery, standardized neuropsychological testing, neurobehavioral questionnaires, a semistructured psychiatric interview, and an assessment of independence in activities of daily living. Results: Relative to HIV- controls, HIV+ individuals showed a mild difference for recognition of sadness (p = .02, d = 0.43), discrimination of happiness (p = .02, d = 0.52), and speed of recognition for fear (p = .04, d = 0.37). HIV+ individuals with HIV-associated neurocognitive disorder (HAND; 20%) had abnormal emotional facial recognition (p = .04; d = .59), and slower recognition of negative facial expressions (p < .01; d = .63-.83), as well as poorer discrimination of happy facial expressions (p < .003, d = .83). Apathy, depression, reduced independence in activities of daily living, and HIV biomarkers were not associated with reduced facial emotion recognition in the HIV+ group. Conclusions: Clinically stable HIV+ individuals show a mild level of emotional processing reduction that is dissociated from neuropsychiatric complaints. Individuals with HAND showed moderate to large emotional processing abnormalities, particularly for the timely recognition of negative expressions (fear, sadness, and anger). These findings warrant a more comprehensive and dynamic evaluation of emotional processing in HIV infection and an investigation of the integrity of the fronto-basal-amygdala circuits.

LanguageEnglish
Pages713-722
Number of pages10
JournalNeuropsychology
Volume26
Issue number6
DOIs
Publication statusPublished - 2012

Fingerprint

HIV Infections
HIV
Facial Expression
Activities of Daily Living
Fear
Emotions
Emotion
AIDS/HIV
Infection
Apathy
Happiness
Anger
Amygdala
Psychiatry
Biomarkers
Recognition (Psychology)
Interviews
Depression

Cite this

Lane, Tammy A. ; Moore, Danielle M. ; Batchelor, Jennifer ; Brew, Bruce J. ; Cysique, Lucette A. / Facial emotional processing in HIV infection : relation to neurocognitive and neuropsychiatric status. In: Neuropsychology. 2012 ; Vol. 26, No. 6. pp. 713-722.
@article{fca05744a71a4dbba1bde46878e76c6a,
title = "Facial emotional processing in HIV infection: relation to neurocognitive and neuropsychiatric status",
abstract = "Objective: To examine facial emotional processing in HIV+ individuals and its relation to neurocognitive performance, neuropsychiatric symptomatology and immune status. Method: Participants included 85 HIV+ individuals (83 males, 2 females) and 25 age-comparable HIV- individuals (22 males, 3 females). Participants underwent The University of Pennsylvania computerized neuropsychological facial emotion test battery, standardized neuropsychological testing, neurobehavioral questionnaires, a semistructured psychiatric interview, and an assessment of independence in activities of daily living. Results: Relative to HIV- controls, HIV+ individuals showed a mild difference for recognition of sadness (p = .02, d = 0.43), discrimination of happiness (p = .02, d = 0.52), and speed of recognition for fear (p = .04, d = 0.37). HIV+ individuals with HIV-associated neurocognitive disorder (HAND; 20{\%}) had abnormal emotional facial recognition (p = .04; d = .59), and slower recognition of negative facial expressions (p < .01; d = .63-.83), as well as poorer discrimination of happy facial expressions (p < .003, d = .83). Apathy, depression, reduced independence in activities of daily living, and HIV biomarkers were not associated with reduced facial emotion recognition in the HIV+ group. Conclusions: Clinically stable HIV+ individuals show a mild level of emotional processing reduction that is dissociated from neuropsychiatric complaints. Individuals with HAND showed moderate to large emotional processing abnormalities, particularly for the timely recognition of negative expressions (fear, sadness, and anger). These findings warrant a more comprehensive and dynamic evaluation of emotional processing in HIV infection and an investigation of the integrity of the fronto-basal-amygdala circuits.",
author = "Lane, {Tammy A.} and Moore, {Danielle M.} and Jennifer Batchelor and Brew, {Bruce J.} and Cysique, {Lucette A.}",
year = "2012",
doi = "10.1037/a0029964",
language = "English",
volume = "26",
pages = "713--722",
journal = "Neuropsychology",
issn = "0894-4105",
publisher = "American Psychological Association Inc.",
number = "6",

}

Facial emotional processing in HIV infection : relation to neurocognitive and neuropsychiatric status. / Lane, Tammy A.; Moore, Danielle M.; Batchelor, Jennifer; Brew, Bruce J.; Cysique, Lucette A.

In: Neuropsychology, Vol. 26, No. 6, 2012, p. 713-722.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Facial emotional processing in HIV infection

T2 - Neuropsychology

AU - Lane, Tammy A.

AU - Moore, Danielle M.

AU - Batchelor, Jennifer

AU - Brew, Bruce J.

AU - Cysique, Lucette A.

PY - 2012

Y1 - 2012

N2 - Objective: To examine facial emotional processing in HIV+ individuals and its relation to neurocognitive performance, neuropsychiatric symptomatology and immune status. Method: Participants included 85 HIV+ individuals (83 males, 2 females) and 25 age-comparable HIV- individuals (22 males, 3 females). Participants underwent The University of Pennsylvania computerized neuropsychological facial emotion test battery, standardized neuropsychological testing, neurobehavioral questionnaires, a semistructured psychiatric interview, and an assessment of independence in activities of daily living. Results: Relative to HIV- controls, HIV+ individuals showed a mild difference for recognition of sadness (p = .02, d = 0.43), discrimination of happiness (p = .02, d = 0.52), and speed of recognition for fear (p = .04, d = 0.37). HIV+ individuals with HIV-associated neurocognitive disorder (HAND; 20%) had abnormal emotional facial recognition (p = .04; d = .59), and slower recognition of negative facial expressions (p < .01; d = .63-.83), as well as poorer discrimination of happy facial expressions (p < .003, d = .83). Apathy, depression, reduced independence in activities of daily living, and HIV biomarkers were not associated with reduced facial emotion recognition in the HIV+ group. Conclusions: Clinically stable HIV+ individuals show a mild level of emotional processing reduction that is dissociated from neuropsychiatric complaints. Individuals with HAND showed moderate to large emotional processing abnormalities, particularly for the timely recognition of negative expressions (fear, sadness, and anger). These findings warrant a more comprehensive and dynamic evaluation of emotional processing in HIV infection and an investigation of the integrity of the fronto-basal-amygdala circuits.

AB - Objective: To examine facial emotional processing in HIV+ individuals and its relation to neurocognitive performance, neuropsychiatric symptomatology and immune status. Method: Participants included 85 HIV+ individuals (83 males, 2 females) and 25 age-comparable HIV- individuals (22 males, 3 females). Participants underwent The University of Pennsylvania computerized neuropsychological facial emotion test battery, standardized neuropsychological testing, neurobehavioral questionnaires, a semistructured psychiatric interview, and an assessment of independence in activities of daily living. Results: Relative to HIV- controls, HIV+ individuals showed a mild difference for recognition of sadness (p = .02, d = 0.43), discrimination of happiness (p = .02, d = 0.52), and speed of recognition for fear (p = .04, d = 0.37). HIV+ individuals with HIV-associated neurocognitive disorder (HAND; 20%) had abnormal emotional facial recognition (p = .04; d = .59), and slower recognition of negative facial expressions (p < .01; d = .63-.83), as well as poorer discrimination of happy facial expressions (p < .003, d = .83). Apathy, depression, reduced independence in activities of daily living, and HIV biomarkers were not associated with reduced facial emotion recognition in the HIV+ group. Conclusions: Clinically stable HIV+ individuals show a mild level of emotional processing reduction that is dissociated from neuropsychiatric complaints. Individuals with HAND showed moderate to large emotional processing abnormalities, particularly for the timely recognition of negative expressions (fear, sadness, and anger). These findings warrant a more comprehensive and dynamic evaluation of emotional processing in HIV infection and an investigation of the integrity of the fronto-basal-amygdala circuits.

UR - http://www.scopus.com/inward/record.url?scp=84874413800&partnerID=8YFLogxK

U2 - 10.1037/a0029964

DO - 10.1037/a0029964

M3 - Article

VL - 26

SP - 713

EP - 722

JO - Neuropsychology

JF - Neuropsychology

SN - 0894-4105

IS - 6

ER -