Factors affecting ¹³C-natural abundance measurement of breath carbon dioxide during surgery

absorption of carbon dioxide during endoscopic procedures

Simon Eaton, Maurizio Pacilli, James Wood, Merrill McHoney, Lucia Corizia, Charlotte Kingsley, Joseph I. Curry, Jane Herod, Ralph Cohen, Agostino Pierro

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The aim of this paper is to review the factors which may affect breath ¹³CO2/¹²CO2 natural abundance in patients undergoing surgery or intensive care. Intravenous glucose administration is a major determinant of the ¹³CO2/ ¹²CO2 of breath as intravenous glucose preparations are almost all derived from cornstarch. In addition, the oxidation of endogenous substrates can affect the ¹³CO2/¹²CO 2 ratio. During many endoscopic procedures, such as laparoscopic surgery, carbon dioxide insufflation is used to provide a working space. As medical CO2 is relatively depleted in ¹³CO2 compared with endogenous and exogenous metabolic CO2 sources, breath ¹³CO2/¹²CO2 measurements can be used to estimate CO2 absorption during these procedures. However, all these factors may also be affected by the bicarbonate pool, making a definitive attribution of changes in breath ¹³CO2/ ¹²CO2 to a single factor problematic.
Original languageEnglish
Pages (from-to)1759-1762
Number of pages4
JournalRapid Communications in Mass Spectrometry
Volume22
Issue number11
DOIs
Publication statusPublished - 2008
Externally publishedYes

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