Factors associated with medication adherence among patients with severe mental disorders in China

A propensity score matching study

Lei Dou, Lili Hu, Nan Zhang, Henry Cutler, Yan Wang, Shunping Li

Research output: Contribution to journalArticle

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Objective: The 686 project provides free essential drugs and follow-up for poor SMD patients, with the purpose of improving patients’ medication adherence and reducing the occurrence of dangerous behaviors. The objective of this research was to determine the factors that influence medication adherence in patients with severe mental disorders (SMD) and analyze whether the 686 program significantly improved patient medication adherence.
Methods: This study was conducted among SMD patients in 686 project and non-project SMD patients in the same community in 11 cities in Shandong Province of China. The data collected included basic patient information and disease treatment information. Medication adherence was divided into good adherence and poor adherence. Propensity score matching (1:1 match) was performed to adjust for differences in baseline characteristics.
Results: One thousand two hundred ninety-two patients receiving free medication assistance policy (686 project group) and 1292 non-policy patients (control group) were analyzed. Patients who received the 686 project group had significantly better medication adherence than the non-policy group patients (92.6% vs.61.2%). Older age and consolidation period were associated with poor adherence, and education level was the positive determinant for adherence.
Conclusion: The 686 project could improve medication adherence to patients with SMD. Additional research will pay attention to medication adherence of patients who are elderly, in consolidation period and lower education levels. It should strengthen the guidance and supervision of patients’ medication and strengthen the health education of family members and patients.
Original languageEnglish
Pages (from-to)1329 - 1339
Number of pages11
JournalPatient Preference and Adherence
Publication statusPublished - 31 Jul 2020

Bibliographical note

Copyright 2020 The Author(s). Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.


  • medication adherence
  • severe mental disorders
  • propensity score matching

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