Failure of moxifloxacin treatment in Mycoplasma genitalium infections due to macrolide and fluoroquinolone resistance

Deborah L. Couldwell, Kaitlin A. Tagg, Neisha J. Jeoffreys, Gwendolyn L. Gilbert

    Research output: Contribution to journalArticlepeer-review

    112 Citations (Scopus)

    Abstract

    Increasing azithromycin treatment failure in sexually transmitted Mycoplasma genitalium infection, is linked to macrolide resistance and second-line treatment relies on the fluoroquinolone, moxifloxacin. We recently detected fluoroquinolone and macrolide resistance-associated mutations in 15% and 43%, respectively, of 143 initial M. genitalium PCR-positive specimens.For a subset of 33 Western Sydney Sexual Health Centre patients, clinical information and results of sequence analysis of M. genitalium macrolide and fluoroquinolone target genes - the 23S rRNA gene, and parC and gyrA, respectively - were used to examine whether mutations were associated with treatment failure. Macrolide resistance-associated mutations correlated with microbiological (p = 0.013) and clinical (p = 0.024) treatment failure, and fluoroquinolone resistance-associated mutations with microbiological moxifloxacin treatment failure (p = 0.005). We describe the first reported cases of clinical and microbiological moxifloxacin treatment failure. Failure of first- and second-line antibiotic treatment of M. genitalium infection is occurring and likely to increase with current treatment strategies.
    Original languageEnglish
    Pages (from-to)822-828
    Number of pages7
    JournalInternational Journal of STD and AIDS
    Volume24
    Issue number10
    DOIs
    Publication statusPublished - 2013

    Keywords

    • antibiotic
    • Australia
    • treatment failure
    • bacterial disease
    • location
    • Mycoplasma genitalium
    • non-gonococcal urethritis
    • resistance
    • Sexually transmitted infections
    • STI
    • treatment

    Fingerprint

    Dive into the research topics of 'Failure of moxifloxacin treatment in Mycoplasma genitalium infections due to macrolide and fluoroquinolone resistance'. Together they form a unique fingerprint.

    Cite this