Fatal human neurologic infection caused by pigeon avian paramyxovirus-1, Australia

Siobhan Hurley*, John Sebastian Eden, John Bingham, Michael Rodriguez, Matthew J. Neave, Alexandra Johnson, Annaleise R. Howard-Jones, Jen Kok, Antoinette Anazodo, Brendan McMullan, David T. Williams, James Watson, Annalisa Solinas, Ki Wook Kim, William Rawlinson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Avian paramyxovirus type 1 (APMV-1) is a virus of birds that results in a range of outcomes, from asymptomatic infections to outbreaks of systemic respiratory and neurologic disease, depending on the virus strain and the avian species affected. Humans are rarely affected; those who are predominantly experience mild conjunctivitis. We report a fatal case of neurologic disease in a 2-year-old immunocompromised child in Australia. Metagenomic sequencing and histopathology identified the causative agent as the pigeon variant of APMV-1. This diagnosis should be considered in neurologic conditions of undefined etiologies. Agnostic metagenomic sequencing methods are useful in such settings to direct diagnostic and therapeutic efforts.

Original languageEnglish
Pages (from-to)2482-2487
Number of pages6
JournalEmerging Infectious Diseases
Issue number12
Publication statusPublished - Dec 2023
Externally publishedYes


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