Fatal human neurologic infection caused by pigeon avian paramyxovirus-1, Australia

Siobhan Hurley; John Sebastian Eden; John Bingham; Michael Rodriguez; Matthew J. Neave; Alexandra Johnson; Annaleise R. Howard-Jones; Jen Kok; Antoinette Anazodo; Brendan McMullan; David T. Williams; James Watson; Annalisa Solinas; Ki Wook Kim; William Rawlinson

doi:10.3201/eid2912.230250

Fatal human neurologic infection caused by pigeon avian paramyxovirus-1, Australia

Siobhan Hurley^*, John Sebastian Eden, John Bingham, Michael Rodriguez, Matthew J. Neave, Alexandra Johnson, Annaleise R. Howard-Jones, Jen Kok, Antoinette Anazodo, Brendan McMullan, David T. Williams, James Watson, Annalisa Solinas, Ki Wook Kim, William Rawlinson

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Avian paramyxovirus type 1 (APMV-1) is a virus of birds that results in a range of outcomes, from asymptomatic infections to outbreaks of systemic respiratory and neurologic disease, depending on the virus strain and the avian species affected. Humans are rarely affected; those who are predominantly experience mild conjunctivitis. We report a fatal case of neurologic disease in a 2-year-old immunocompromised child in Australia. Metagenomic sequencing and histopathology identified the causative agent as the pigeon variant of APMV-1. This diagnosis should be considered in neurologic conditions of undefined etiologies. Agnostic metagenomic sequencing methods are useful in such settings to direct diagnostic and therapeutic efforts.

Original language	English
Pages (from-to)	2482-2487
Number of pages	6
Journal	Emerging Infectious Diseases
Volume	29
Issue number	12
DOIs	https://doi.org/10.3201/eid2912.230250
Publication status	Published - Dec 2023
Externally published	Yes

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Hurley, S., Eden, J. S., Bingham, J., Rodriguez, M., Neave, M. J., Johnson, A., Howard-Jones, A. R., Kok, J., Anazodo, A., McMullan, B., Williams, D. T., Watson, J., Solinas, A., Kim, K. W., & Rawlinson, W. (2023). Fatal human neurologic infection caused by pigeon avian paramyxovirus-1, Australia. Emerging Infectious Diseases, 29(12), 2482-2487. https://doi.org/10.3201/eid2912.230250

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title = "Fatal human neurologic infection caused by pigeon avian paramyxovirus-1, Australia",

abstract = "Avian paramyxovirus type 1 (APMV-1) is a virus of birds that results in a range of outcomes, from asymptomatic infections to outbreaks of systemic respiratory and neurologic disease, depending on the virus strain and the avian species affected. Humans are rarely affected; those who are predominantly experience mild conjunctivitis. We report a fatal case of neurologic disease in a 2-year-old immunocompromised child in Australia. Metagenomic sequencing and histopathology identified the causative agent as the pigeon variant of APMV-1. This diagnosis should be considered in neurologic conditions of undefined etiologies. Agnostic metagenomic sequencing methods are useful in such settings to direct diagnostic and therapeutic efforts.",

author = "Siobhan Hurley and Eden, {John Sebastian} and John Bingham and Michael Rodriguez and Neave, {Matthew J.} and Alexandra Johnson and Howard-Jones, {Annaleise R.} and Jen Kok and Antoinette Anazodo and Brendan McMullan and Williams, {David T.} and James Watson and Annalisa Solinas and Kim, {Ki Wook} and William Rawlinson",

year = "2023",

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doi = "10.3201/eid2912.230250",

language = "English",

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pages = "2482--2487",

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Hurley, S, Eden, JS, Bingham, J, Rodriguez, M, Neave, MJ, Johnson, A, Howard-Jones, AR, Kok, J, Anazodo, A, McMullan, B, Williams, DT, Watson, J, Solinas, A, Kim, KW & Rawlinson, W 2023, 'Fatal human neurologic infection caused by pigeon avian paramyxovirus-1, Australia', Emerging Infectious Diseases, vol. 29, no. 12, pp. 2482-2487. https://doi.org/10.3201/eid2912.230250

TY - JOUR

T1 - Fatal human neurologic infection caused by pigeon avian paramyxovirus-1, Australia

AU - Hurley, Siobhan

AU - Eden, John Sebastian

AU - Bingham, John

AU - Rodriguez, Michael

AU - Neave, Matthew J.

AU - Johnson, Alexandra

AU - Howard-Jones, Annaleise R.

AU - Kok, Jen

AU - Anazodo, Antoinette

AU - McMullan, Brendan

AU - Williams, David T.

AU - Watson, James

AU - Solinas, Annalisa

AU - Kim, Ki Wook

AU - Rawlinson, William

PY - 2023/12

Y1 - 2023/12

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AB - Avian paramyxovirus type 1 (APMV-1) is a virus of birds that results in a range of outcomes, from asymptomatic infections to outbreaks of systemic respiratory and neurologic disease, depending on the virus strain and the avian species affected. Humans are rarely affected; those who are predominantly experience mild conjunctivitis. We report a fatal case of neurologic disease in a 2-year-old immunocompromised child in Australia. Metagenomic sequencing and histopathology identified the causative agent as the pigeon variant of APMV-1. This diagnosis should be considered in neurologic conditions of undefined etiologies. Agnostic metagenomic sequencing methods are useful in such settings to direct diagnostic and therapeutic efforts.

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DO - 10.3201/eid2912.230250

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AN - SCOPUS:85178537805

SN - 1080-6040

VL - 29

SP - 2482

EP - 2487

JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

IS - 12

ER -

Fatal human neurologic infection caused by pigeon avian paramyxovirus-1, Australia

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