Femtogram detection of cytokines in a direct dot-blot assay using SERS microspectroscopy and hydrophilically stabilized Au-Ag nanoshells

Yuling Wang; Mohammad Salehi; Max Schütz; Sebastian Schlücker

doi:10.1039/c3cc48633h

Femtogram detection of cytokines in a direct dot-blot assay using SERS microspectroscopy and hydrophilically stabilized Au-Ag nanoshells

Yuling Wang, Mohammad Salehi, Max Schütz, Sebastian Schlücker^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

44 Citations (Scopus)

Abstract

Rapid parallel detection of two cytokines (IL-6 and IL-8) with femtogram sensitivity in a simple direct dot-blot assay is demonstrated. The microspectroscopic SERS acquisition scheme employs rationally designed, hydrophilically stabilized Au-Ag nanoshells as SERS labels, which are optimized for signal enhancement upon red laser excitation.

Original language	English
Pages (from-to)	2711-2714
Number of pages	4
Journal	Chemical Communications
Volume	50
Issue number	21
DOIs	https://doi.org/10.1039/c3cc48633h
Publication status	Published - 14 Mar 2014
Externally published	Yes

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10.1039/c3cc48633h

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abstract = "Rapid parallel detection of two cytokines (IL-6 and IL-8) with femtogram sensitivity in a simple direct dot-blot assay is demonstrated. The microspectroscopic SERS acquisition scheme employs rationally designed, hydrophilically stabilized Au-Ag nanoshells as SERS labels, which are optimized for signal enhancement upon red laser excitation.",

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AU - Wang, Yuling

AU - Salehi, Mohammad

AU - Schütz, Max

AU - Schlücker, Sebastian

PY - 2014/3/14

Y1 - 2014/3/14

N2 - Rapid parallel detection of two cytokines (IL-6 and IL-8) with femtogram sensitivity in a simple direct dot-blot assay is demonstrated. The microspectroscopic SERS acquisition scheme employs rationally designed, hydrophilically stabilized Au-Ag nanoshells as SERS labels, which are optimized for signal enhancement upon red laser excitation.

AB - Rapid parallel detection of two cytokines (IL-6 and IL-8) with femtogram sensitivity in a simple direct dot-blot assay is demonstrated. The microspectroscopic SERS acquisition scheme employs rationally designed, hydrophilically stabilized Au-Ag nanoshells as SERS labels, which are optimized for signal enhancement upon red laser excitation.

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U2 - 10.1039/c3cc48633h

DO - 10.1039/c3cc48633h

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AN - SCOPUS:84894178262

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JO - Chemical Communications

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ER -

Femtogram detection of cytokines in a direct dot-blot assay using SERS microspectroscopy and hydrophilically stabilized Au-Ag nanoshells

Abstract

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