Femtogram detection of cytokines in a direct dot-blot assay using SERS microspectroscopy and hydrophilically stabilized Au-Ag nanoshells

Yuling Wang, Mohammad Salehi, Max Schütz, Sebastian Schlücker*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)

Abstract

Rapid parallel detection of two cytokines (IL-6 and IL-8) with femtogram sensitivity in a simple direct dot-blot assay is demonstrated. The microspectroscopic SERS acquisition scheme employs rationally designed, hydrophilically stabilized Au-Ag nanoshells as SERS labels, which are optimized for signal enhancement upon red laser excitation.

Original languageEnglish
Pages (from-to)2711-2714
Number of pages4
JournalChemical Communications
Volume50
Issue number21
DOIs
Publication statusPublished - 14 Mar 2014
Externally publishedYes

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