Fetus in fetu: molecular analysis of a fetiform mass

A. Hing, J. Corteville, R. P. Foglia, D. P. Bliss, H. Donis-Keller, S. B. Dowton*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)

Abstract

Fetus-in-fetu is a rare condition presenting as a calcified intra- abdominal mass in the newborn infant. Over 50 cases of fetus-in-fetu have been reported since 1800. Karyotype analysis in 8 cases and protein polymorphisms in 4 documented identical findings in the host and fetiform mass. We report a case of fetus-in-fetu in a newborn female including cytogenetic and molecular studies of both the host and mass. Genotypic information from 7 polymerase chain reaction (PCR) assays representing 4 chromosomes demonstrates heterozygous and identical alleles in the infant and fetus-in-fetu at all loci studied. A review of the literature is provided including a discussion regarding the impact of molecular data on present hypotheses of fetus-in-fetu pathogenesis.

Original languageEnglish
Pages (from-to)333-341
Number of pages9
JournalAmerican Journal of Medical Genetics
Volume47
Issue number3
Publication statusPublished - 1993
Externally publishedYes

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