Financial competing interests were associated with favorable conclusions and greater author productivity in nonsystematic reviews of neuraminidase inhibitors

Adam G. Dunn, Xujuan Zhou, Joel Hudgins, Diana Arachi, Kenneth D. Mandl, Enrico Coiera, Florence T. Bourgeois

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Objective To characterize the conclusions and production of nonsystematic reviews about neuraminidase inhibitors relative to financial competing interests held by the authors. Study Design and Setting We searched for articles about neuraminidase inhibitors and influenza (January 2005 to April 2015), identifying nonsystematic reviews and grading them according to the favorable/nonfavorable presentation of evidence on safety and efficacy. We recorded financial competing interests disclosed in the reviews and from other articles written by their authors. We measured associations between competing interests, author productivity, and conclusions. Results Among 213 nonsystematic reviews, 138 (65%) presented favorable conclusions. Financial competing interests were identified for 26% (137/532) of authors; 51% (108/213) of reviews were associated with a financial competing interest. Reviews produced exclusively by authors with financial competing interests (33%; 71/213) were more likely to present favorable conclusions than reviews with no competing interests (risk ratio 1.27; 95% confidence interval 1.03–1.55). Authors with financial competing interests published more articles about neuraminidase inhibitors than their counterparts. Conclusion Half of nonsystematic reviews about neuraminidase inhibitors included an author with a financial competing interest. Reviews produced exclusively by these authors were more likely to present favorable conclusions, and authors with financial competing interests published a greater number of reviews.

LanguageEnglish
Pages43-49
Number of pages7
JournalJournal of Clinical Epidemiology
Volume80
DOIs
Publication statusPublished - 1 Dec 2016

Fingerprint

Neuraminidase
Human Influenza
Odds Ratio
Confidence Intervals
Safety

Keywords

  • Bibliometrics
  • Competing interests
  • Neuraminidase inhibitors
  • Oseltamivir
  • Review literature as topic
  • Zanamivir

Cite this

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title = "Financial competing interests were associated with favorable conclusions and greater author productivity in nonsystematic reviews of neuraminidase inhibitors",
abstract = "Objective To characterize the conclusions and production of nonsystematic reviews about neuraminidase inhibitors relative to financial competing interests held by the authors. Study Design and Setting We searched for articles about neuraminidase inhibitors and influenza (January 2005 to April 2015), identifying nonsystematic reviews and grading them according to the favorable/nonfavorable presentation of evidence on safety and efficacy. We recorded financial competing interests disclosed in the reviews and from other articles written by their authors. We measured associations between competing interests, author productivity, and conclusions. Results Among 213 nonsystematic reviews, 138 (65{\%}) presented favorable conclusions. Financial competing interests were identified for 26{\%} (137/532) of authors; 51{\%} (108/213) of reviews were associated with a financial competing interest. Reviews produced exclusively by authors with financial competing interests (33{\%}; 71/213) were more likely to present favorable conclusions than reviews with no competing interests (risk ratio 1.27; 95{\%} confidence interval 1.03–1.55). Authors with financial competing interests published more articles about neuraminidase inhibitors than their counterparts. Conclusion Half of nonsystematic reviews about neuraminidase inhibitors included an author with a financial competing interest. Reviews produced exclusively by these authors were more likely to present favorable conclusions, and authors with financial competing interests published a greater number of reviews.",
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author = "Dunn, {Adam G.} and Xujuan Zhou and Joel Hudgins and Diana Arachi and Mandl, {Kenneth D.} and Enrico Coiera and Bourgeois, {Florence T.}",
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Financial competing interests were associated with favorable conclusions and greater author productivity in nonsystematic reviews of neuraminidase inhibitors. / Dunn, Adam G.; Zhou, Xujuan; Hudgins, Joel; Arachi, Diana; Mandl, Kenneth D.; Coiera, Enrico; Bourgeois, Florence T.

In: Journal of Clinical Epidemiology, Vol. 80, 01.12.2016, p. 43-49.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Financial competing interests were associated with favorable conclusions and greater author productivity in nonsystematic reviews of neuraminidase inhibitors

AU - Dunn, Adam G.

AU - Zhou, Xujuan

AU - Hudgins, Joel

AU - Arachi, Diana

AU - Mandl, Kenneth D.

AU - Coiera, Enrico

AU - Bourgeois, Florence T.

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N2 - Objective To characterize the conclusions and production of nonsystematic reviews about neuraminidase inhibitors relative to financial competing interests held by the authors. Study Design and Setting We searched for articles about neuraminidase inhibitors and influenza (January 2005 to April 2015), identifying nonsystematic reviews and grading them according to the favorable/nonfavorable presentation of evidence on safety and efficacy. We recorded financial competing interests disclosed in the reviews and from other articles written by their authors. We measured associations between competing interests, author productivity, and conclusions. Results Among 213 nonsystematic reviews, 138 (65%) presented favorable conclusions. Financial competing interests were identified for 26% (137/532) of authors; 51% (108/213) of reviews were associated with a financial competing interest. Reviews produced exclusively by authors with financial competing interests (33%; 71/213) were more likely to present favorable conclusions than reviews with no competing interests (risk ratio 1.27; 95% confidence interval 1.03–1.55). Authors with financial competing interests published more articles about neuraminidase inhibitors than their counterparts. Conclusion Half of nonsystematic reviews about neuraminidase inhibitors included an author with a financial competing interest. Reviews produced exclusively by these authors were more likely to present favorable conclusions, and authors with financial competing interests published a greater number of reviews.

AB - Objective To characterize the conclusions and production of nonsystematic reviews about neuraminidase inhibitors relative to financial competing interests held by the authors. Study Design and Setting We searched for articles about neuraminidase inhibitors and influenza (January 2005 to April 2015), identifying nonsystematic reviews and grading them according to the favorable/nonfavorable presentation of evidence on safety and efficacy. We recorded financial competing interests disclosed in the reviews and from other articles written by their authors. We measured associations between competing interests, author productivity, and conclusions. Results Among 213 nonsystematic reviews, 138 (65%) presented favorable conclusions. Financial competing interests were identified for 26% (137/532) of authors; 51% (108/213) of reviews were associated with a financial competing interest. Reviews produced exclusively by authors with financial competing interests (33%; 71/213) were more likely to present favorable conclusions than reviews with no competing interests (risk ratio 1.27; 95% confidence interval 1.03–1.55). Authors with financial competing interests published more articles about neuraminidase inhibitors than their counterparts. Conclusion Half of nonsystematic reviews about neuraminidase inhibitors included an author with a financial competing interest. Reviews produced exclusively by these authors were more likely to present favorable conclusions, and authors with financial competing interests published a greater number of reviews.

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