Abstract
We discuss the assessment of age- and time-specific disease incidence rising prevalence data. A method is described for conveniently fitting a discrete-time multiplicative model, subject to positivity constraints, using the EM-algorithm. Together with smoothing, it allows essentially nonparametric assessment of incidence trends. The method is illustrated using previously analyzed data on toxoplasmosis.
Original language | English |
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Pages (from-to) | 492-499 |
Number of pages | 8 |
Journal | Biometrics |
Volume | 52 |
Issue number | 2 |
DOIs | |
Publication status | Published - Jun 1996 |
Externally published | Yes |
Keywords
- Cross-sectional data
- EM-algorithm
- Incidence and prevalence
- Multiplicative age time models
- Smoothing
- Toxoplasmosis