Fluorinated N-heterocycles as conformationally diverse bioactives for drug discovery

N-heterocycles and their fluorinated analogues are prevalent in many fields of chemistry. In particular, they are an important class of compounds for bioactivity and drug discovery. The review here focuses on recent strategies in designing and accessing fluorinated and saturated N-heterocycles with conformational diversity for exploring new protein-ligand interactions. Some of the examples highlight the continuous investigation from the authors on fluorinated azepanes with complex conformational preferences.