Force measurements for cancer cells

Vivek Rajasekharan, Varun K A Sreenivasan, Brenda Farrell*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


During cytoskeleton remodeling, cancer cells generate force at the plasma membrane that originates from chemical motors (e.g., actin). This force (pN) and its time course reflect the on and off-rates of the motors. We describe the design and calibration of a force-measuring device (i.e., optical tweezers) that is used to monitor this force and its time course at the edge of a cell, with particular emphasis on the temporal resolution of the instrument.

Original languageEnglish
Title of host publicationCancer nanotechnology
Subtitle of host publicationmethods and protocols
EditorsReema Zeineldin
Place of PublicationNew York, NY
PublisherHumana Press
Number of pages34
ISBN (Electronic)9781493966462
ISBN (Print)9781493966448
Publication statusPublished - 2017

Publication series

NameMethods in Molecular Biology
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029


  • Actin
  • Cell mobility
  • Cytoskeleton
  • Filopodium
  • Membrane force
  • Membrane tube
  • Motor kinetics
  • Noise of signal
  • Optical tweezers
  • Time constant

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