Fractal-based analysis of histological features of brain tumors

Omar S. Al-Kadi, Antonio Di Ieva

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


The structural complexity of brain tumor tissue represents a major challenge for effective histopathological diagnosis. Tumor vasculature is known to be heterogeneous, and mixtures of patterns are usually present. Therefore, extracting key descriptive features for accurate quantification is not a straightforward task. Several steps are involved in the texture analysis process where tissue heterogeneity contributes to the variability of the results. One of the interesting aspects of the brain lies in its fractal nature. Many regions within the brain tissue yield similar statistical properties at different scales of magnification. Fractal-based analysis of the histological features of brain tumors can reveal the underlying complexity of tissue structure and angiostructure, also providing an indication of tissue abnormality development. It can further be used to quantify the chaotic signature of disease to distinguish between different temporal tumor stages and histopathological grades. Brain meningioma subtype classifications' improvement from histopathological images is the main focus of this chapter. Meningioma tissue texture exhibits a wide range of histological patterns whereby a single slide may show a combination of multiple patterns. Distinctive fractal patterns quantified in a multiresolution manner would be for better spatial relationship representation. Fractal features extracted from textural tissue patterns can be useful in characterizing meningioma tumors in terms of subtype classification, a challenging problem compared to histological grading, and furthermore can provide an objective measure for quantifying subtle features within subtypes that are hard to discriminate.

Original languageEnglish
Title of host publicationThe fractal geometry of the brain
EditorsAntonio Di Ieva
Place of PublicationSwitzerland
PublisherSpringer, Springer Nature
Number of pages24
ISBN (Electronic)9783031476068
ISBN (Print)9783031476051
Publication statusPublished - 10 Mar 2024

Publication series

NameAdvances in Neurobiology
PublisherSpringer, Springer Nature
ISSN (Print)2190-5215
ISSN (Electronic)2190-5223


  • Brain histopathology
  • Fractal dimension
  • Meningioma
  • Pattern classification
  • Texture analysis
  • Tissue characterization


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