Free water elimination improves tractography through multiple sclerosis lesions

Brittany Gilchrist, Sidong Liu, Chenyu Wang, Ofer Pasternak, Yuyi You, Alexander Klistorner

Research output: Contribution to conferencePaperResearchpeer-review

Abstract

Axonal loss within chronic MS lesions is typically accompanied by increase of extra-cellular space. Reduction of anisotropy caused by this excessive extra-cellular water may limit the ability of tractography techniques to accurately detect fibre bundles. The aim of this study was to examine if application of free water elimination (FWE) algorithm may improve deterministic tractography through MS lesions. We show that elimination of free water markedly increases detection of lesional fibre bundles. While this effect was observed in the majority of lesions, it was more apparent in lesions with small initial number of fibres and in lesions categorised as severely damaged.

Conference

ConferenceJoint Annual Meeting ISMRM-ESMRMB, 16-21 June 2018, Paris, France
CountryFrance
CityParis
Period16/06/1821/06/18

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Multiple Sclerosis
Water
Anisotropy

Cite this

Gilchrist, B., Liu, S., Wang, C., Pasternak, O., You, Y., & Klistorner, A. (2018). Free water elimination improves tractography through multiple sclerosis lesions. Paper presented at Joint Annual Meeting ISMRM-ESMRMB, 16-21 June 2018, Paris, France, Paris, France.
Gilchrist, Brittany ; Liu, Sidong ; Wang, Chenyu ; Pasternak, Ofer ; You, Yuyi ; Klistorner, Alexander. / Free water elimination improves tractography through multiple sclerosis lesions. Paper presented at Joint Annual Meeting ISMRM-ESMRMB, 16-21 June 2018, Paris, France, Paris, France.3 p.
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abstract = "Axonal loss within chronic MS lesions is typically accompanied by increase of extra-cellular space. Reduction of anisotropy caused by this excessive extra-cellular water may limit the ability of tractography techniques to accurately detect fibre bundles. The aim of this study was to examine if application of free water elimination (FWE) algorithm may improve deterministic tractography through MS lesions. We show that elimination of free water markedly increases detection of lesional fibre bundles. While this effect was observed in the majority of lesions, it was more apparent in lesions with small initial number of fibres and in lesions categorised as severely damaged.",
author = "Brittany Gilchrist and Sidong Liu and Chenyu Wang and Ofer Pasternak and Yuyi You and Alexander Klistorner",
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Gilchrist, B, Liu, S, Wang, C, Pasternak, O, You, Y & Klistorner, A 2018, 'Free water elimination improves tractography through multiple sclerosis lesions' Paper presented at Joint Annual Meeting ISMRM-ESMRMB, 16-21 June 2018, Paris, France, Paris, France, 16/06/18 - 21/06/18, .

Free water elimination improves tractography through multiple sclerosis lesions. / Gilchrist, Brittany; Liu, Sidong; Wang, Chenyu; Pasternak, Ofer; You, Yuyi; Klistorner, Alexander.

2018. Paper presented at Joint Annual Meeting ISMRM-ESMRMB, 16-21 June 2018, Paris, France, Paris, France.

Research output: Contribution to conferencePaperResearchpeer-review

TY - CONF

T1 - Free water elimination improves tractography through multiple sclerosis lesions

AU - Gilchrist, Brittany

AU - Liu, Sidong

AU - Wang, Chenyu

AU - Pasternak, Ofer

AU - You, Yuyi

AU - Klistorner, Alexander

PY - 2018/6

Y1 - 2018/6

N2 - Axonal loss within chronic MS lesions is typically accompanied by increase of extra-cellular space. Reduction of anisotropy caused by this excessive extra-cellular water may limit the ability of tractography techniques to accurately detect fibre bundles. The aim of this study was to examine if application of free water elimination (FWE) algorithm may improve deterministic tractography through MS lesions. We show that elimination of free water markedly increases detection of lesional fibre bundles. While this effect was observed in the majority of lesions, it was more apparent in lesions with small initial number of fibres and in lesions categorised as severely damaged.

AB - Axonal loss within chronic MS lesions is typically accompanied by increase of extra-cellular space. Reduction of anisotropy caused by this excessive extra-cellular water may limit the ability of tractography techniques to accurately detect fibre bundles. The aim of this study was to examine if application of free water elimination (FWE) algorithm may improve deterministic tractography through MS lesions. We show that elimination of free water markedly increases detection of lesional fibre bundles. While this effect was observed in the majority of lesions, it was more apparent in lesions with small initial number of fibres and in lesions categorised as severely damaged.

M3 - Paper

ER -

Gilchrist B, Liu S, Wang C, Pasternak O, You Y, Klistorner A. Free water elimination improves tractography through multiple sclerosis lesions. 2018. Paper presented at Joint Annual Meeting ISMRM-ESMRMB, 16-21 June 2018, Paris, France, Paris, France.