Frequency-dependent neuromuscular blockade by textilotoxin in vivo

D. R. Lloyd, G. M. Nicholson*, I. Spence, M. Connor, M. I. Tyler, M. E H Howden

*Corresponding author for this work

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

D. R. Lloyd, G. M. Nicholson, I. Spence, M. Connor, M. I. Tyler and M. E. H. Howden. Frequency-dependent neuromuscular blockade by textilotoxin in vivo. Toxicon 29, 1266-1269, 1991.-The effect of stimulation frequency on the timecourse of neuromuscular blockade, following the administration of textilotoxin (20 μg/kg) or β-bungarotoxin (50 μ/kg), was examined in the interdigital muscles of the hindlimb in anaesthetized mice. While the time of death was variable, neuromuscular blockade of the interdigital muscles occurred at the same time as respiratory failure with both textilotoxin and β-bungarotoxin only at stimulation rates of 0.5 Hz and above. Textilotoxin (50 μg/kg) produced an increase in the heart rate prior to death but no change in the shape of the electrocardiogram.

Original languageEnglish
Pages (from-to)1266-1269
Number of pages4
JournalToxicon
Volume29
Issue number10
DOIs
Publication statusPublished - 1991
Externally publishedYes

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    Lloyd, D. R., Nicholson, G. M., Spence, I., Connor, M., Tyler, M. I., & Howden, M. E. H. (1991). Frequency-dependent neuromuscular blockade by textilotoxin in vivo. Toxicon, 29(10), 1266-1269. https://doi.org/10.1016/0041-0101(91)90199-2