TY - JOUR
T1 - From role of gut microbiota to microbial-based therapies in type 2-diabetes
AU - Ebrahimzadeh Leylabadlo, Hamed
AU - Sanaie, Sarvin
AU - Sadeghpour Heravi, Fatemah
AU - Ahmadian, Zainab
AU - Ghotaslou, Reza
PY - 2020/7
Y1 - 2020/7
N2 - The incidence of type 2 diabetes mellitus (T2DM) has increased dramatically at an alarming level around the world.T2DM is associated with changeable risk factors in lifestyle as well as genetic and family associated risk factors. More importantly, imbalanced or impaired gut microbial distribution (dysbiosis) has been reported as a contributing risk factor in insulin resistance progression in T2DM. Dysbiosis may restructure the metabolic and functional pathways in the intestine which are involved in the development of T2DM. However, several studies have indicated the constructive and helpful effect of prebiotics, probiotics, and fecal microbiota transplantation (FMT) on the improvement of gut microbiota (GM) and accordingly host metabolism. In this review, the association between GM and T2DM have been evaluated and the role of prebiotics, probiotics and FMT, as potential therapeutic approaches have been discussed. Relevant studies were obtained randomly from online databases such as PubMed/Medline and ISI Web of Science.
AB - The incidence of type 2 diabetes mellitus (T2DM) has increased dramatically at an alarming level around the world.T2DM is associated with changeable risk factors in lifestyle as well as genetic and family associated risk factors. More importantly, imbalanced or impaired gut microbial distribution (dysbiosis) has been reported as a contributing risk factor in insulin resistance progression in T2DM. Dysbiosis may restructure the metabolic and functional pathways in the intestine which are involved in the development of T2DM. However, several studies have indicated the constructive and helpful effect of prebiotics, probiotics, and fecal microbiota transplantation (FMT) on the improvement of gut microbiota (GM) and accordingly host metabolism. In this review, the association between GM and T2DM have been evaluated and the role of prebiotics, probiotics and FMT, as potential therapeutic approaches have been discussed. Relevant studies were obtained randomly from online databases such as PubMed/Medline and ISI Web of Science.
KW - Microbiome
KW - Microbiota
KW - Prebiotics
KW - Probiotics
KW - Type 2 diabetes
UR - http://www.scopus.com/inward/record.url?scp=85080996943&partnerID=8YFLogxK
U2 - 10.1016/j.meegid.2020.104268
DO - 10.1016/j.meegid.2020.104268
M3 - Review article
C2 - 32126303
AN - SCOPUS:85080996943
VL - 81
SP - 1
EP - 12
JO - Infection, Genetics and Evolution
JF - Infection, Genetics and Evolution
SN - 1567-1348
M1 - 104268
ER -