From role of gut microbiota to microbial-based therapies in type 2-diabetes

Hamed Ebrahimzadeh Leylabadlo, Sarvin Sanaie, Fatemah Sadeghpour Heravi, Zainab Ahmadian, Reza Ghotaslou*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

62 Citations (Scopus)


The incidence of type 2 diabetes mellitus (T2DM) has increased dramatically at an alarming level around the world.T2DM is associated with changeable risk factors in lifestyle as well as genetic and family associated risk factors. More importantly, imbalanced or impaired gut microbial distribution (dysbiosis) has been reported as a contributing risk factor in insulin resistance progression in T2DM. Dysbiosis may restructure the metabolic and functional pathways in the intestine which are involved in the development of T2DM. However, several studies have indicated the constructive and helpful effect of prebiotics, probiotics, and fecal microbiota transplantation (FMT) on the improvement of gut microbiota (GM) and accordingly host metabolism. In this review, the association between GM and T2DM have been evaluated and the role of prebiotics, probiotics and FMT, as potential therapeutic approaches have been discussed. Relevant studies were obtained randomly from online databases such as PubMed/Medline and ISI Web of Science.

Original languageEnglish
Article number104268
Pages (from-to)1-12
Number of pages12
JournalInfection, Genetics and Evolution
Publication statusPublished - Jul 2020


  • Microbiome
  • Microbiota
  • Prebiotics
  • Probiotics
  • Type 2 diabetes


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