Fuligopyrones from the fruiting bodies of myxomycete Fuligo septica offer short-term protection from abiotic stress induced by UV radiation

Scott A. Minns, Simon Bowles, Ernest Lacey, John A. Kalaitzis, Daniel Vuong, Mark S. Butler, Andrew M. Piggott*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)
27 Downloads (Pure)

Abstract

The myxomycete Fuligo septica, colloquially referred to as “dog vomit fungus”, forms vibrant yellow fruiting bodies (aethalia) on wood chips during warm and humid conditions in spring. In 2018, ideal climatic conditions in Sydney, Australia, provided a rare opportunity to access abundant quantities of F. septica aethalia, which enabled the isolation, purification, structure elucidation, and biological screening of two avenalumamide pyrones, fuligopyrone (1) and fuligopyrone B (2). While 1 and 2 did not exhibit any appreciable biological activity, their significant UV absorption at 325 nm suggested they may be acting as transient sunscreens to help protect the fruiting mass from exposure to sunlight. In support of this hypothesis, exposing a solution of 2 to direct sunlight for 5 min resulted in rapid equilibration with a mixture of 2E,4Z-fuligopyrone B (10) and 2Z,4E-fuligopyrone B (11) photoisomers.

Original languageEnglish
Pages (from-to)633-637
Number of pages5
JournalJournal of Natural Products
Volume86
Issue number3
Early online date18 Jan 2023
DOIs
Publication statusPublished - 24 Mar 2023

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