Functional diversity of actin cytoskeleton in neurons and its regulation by tropomyosin

Galina Schevzov*, Nikki Margarita Curthoys, Peter William Gunning, Thomas Fath

*Corresponding author for this work

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Neurons comprise functionally, molecularly, and spatially distinct subcellular compartments which include the soma, dendrites, axon, branches, dendritic spines, and growth cones. In this chapter, we detail the remarkable ability of the neuronal cytoskeleton to exquisitely regulate all these cytoplasmic distinct partitions, with particular emphasis on the microfilament system and its plethora of associated proteins. Importance will be given to the family of actin-associated proteins, tropomyosin, in defining distinct actin filament populations. The ability of tropomyosin isoforms to regulate the access of actin-binding proteins to the filaments is believed to define the structural diversity and dynamics of actin filaments and ultimately be responsible for the functional outcome of these filaments.

Original languageEnglish
Pages (from-to)33-94
Number of pages62
JournalInternational Review of Cell and Molecular Biology
Volume298
DOIs
Publication statusPublished - 14 Aug 2012
Externally publishedYes

Keywords

  • Actin cytoskeleton
  • Isoforms
  • Neurological diseases
  • Neuron
  • Tropomyosin
  • Tropomyosin isoform

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