Functional effects of genetic polymorphism in inflammatory genes in subjective memory complainers

Simon Lau, Kristyn Alissa Bates*, Hamid R. Sohrabi, Mark Rodrigues, Georgia Martins, Satvinder S. Dhaliwal, Kevin Taddei, Simon M. Laws, Ian J. Martins, Francis L. Mastaglia, Jonathan K. Foster, Jacqueline K. Phillips, Ralph N. Martins

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    9 Citations (Scopus)

    Abstract

    A number of genetic risk factors have been identified for Alzheimer's disease (AD) including genes involved in the inflammatory response (interleukin 1A, [IL-1α (-889)], interleukin 1B (IL-1β [+3953]), and tumor necrosis factor (TNF [-308 and -850]). We investigated the prevalence and functional consequences (baseline cognitive performance, plasma cytokine levels) of possession of these putative genetic risk factors within a group of subjective memory complainers (SMC, n = 226) and age and sex matched noncomplainers (NMC, n = 167). We observed no effect of any of the genetic factors investigated on cognitive performance. Further, there was no difference in the frequency of the disease-associated alleles, or cytokine levels between subjective memory complainers and noncomplainer participants. There was no relationship between TNF polymorphisms and TNF levels. There was a significant increase in plasma IL-1β levels in those homozygous for the disease-associated allele (i.e., IL-1β +3953 TT). Follow-up longitudinal assessments on this cohort will provide insight as to how these polymorphisms may affect the risk of cognitive decline over time.

    Original languageEnglish
    Pages (from-to)1054-1056
    Number of pages3
    JournalNeurobiology of Aging
    Volume33
    Issue number6
    DOIs
    Publication statusPublished - Jun 2012

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