Functionality and stability of heparin immobilized onto poly (dimethylsiloxane)

S. Thorslund*, J. Sanchez, R. Larsson, F. Nikolajeff, J. Bergquist

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference proceeding contribution

Abstract

We demonstrate a new grade of non-covalent heparin surface that adds efficient anticoagulant property to the poly(dimethylsiloxane) (PDMS) material. The surface modification is a simple and fast one-step process performed at neutral pH, optimal when working with closed microsystems. The heparin formed a uniform and functional coating on hydrophobic PDMS. evaluated with fluorophore labeled antithrombin. In addition, long- Term studies revealed that the immobilized heparin was more or less stable in microchannels over a time of three weeks.

Original languageEnglish
Title of host publicationMicro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference: 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherTransducer Research Foundation
Pages1270-1272
Number of pages3
Volume1
ISBN (Print)0974361119, 9780974361116
Publication statusPublished - 2005
Event9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2005 - Boston, MA, United States
Duration: 9 Oct 200513 Oct 2005

Other

Other9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2005
CountryUnited States
CityBoston, MA
Period9/10/0513/10/05

Keywords

  • Biocompatible
  • Heparin
  • PDMS
  • Surface modification

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