Functionality and stability of heparin immobilized onto poly (dimethylsiloxane)

S. Thorslund; J. Sanchez; R. Larsson; F. Nikolajeff; J. Bergquist

Functionality and stability of heparin immobilized onto poly (dimethylsiloxane)

S. Thorslund^*, J. Sanchez, R. Larsson, F. Nikolajeff, J. Bergquist

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference proceeding contribution › peer-review

Abstract

We demonstrate a new grade of non-covalent heparin surface that adds efficient anticoagulant property to the poly(dimethylsiloxane) (PDMS) material. The surface modification is a simple and fast one-step process performed at neutral pH, optimal when working with closed microsystems. The heparin formed a uniform and functional coating on hydrophobic PDMS. evaluated with fluorophore labeled antithrombin. In addition, long- Term studies revealed that the immobilized heparin was more or less stable in microchannels over a time of three weeks.

Original language	English
Title of host publication	Micro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference: 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences
Publisher	Transducer Research Foundation
Pages	1270-1272
Number of pages	3
Volume	1
ISBN (Print)	0974361119, 9780974361116
Publication status	Published - 2005
Event	9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2005 - Boston, MA, United States Duration: 9 Oct 2005 → 13 Oct 2005

Other

Other	9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2005
Country/Territory	United States
City	Boston, MA
Period	9/10/05 → 13/10/05

Keywords

Biocompatible
Heparin
PDMS
Surface modification

Cite this

Thorslund, S., Sanchez, J., Larsson, R., Nikolajeff, F., & Bergquist, J. (2005). Functionality and stability of heparin immobilized onto poly (dimethylsiloxane). In Micro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference: 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences (Vol. 1, pp. 1270-1272). Transducer Research Foundation.

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title = "Functionality and stability of heparin immobilized onto poly (dimethylsiloxane)",

abstract = "We demonstrate a new grade of non-covalent heparin surface that adds efficient anticoagulant property to the poly(dimethylsiloxane) (PDMS) material. The surface modification is a simple and fast one-step process performed at neutral pH, optimal when working with closed microsystems. The heparin formed a uniform and functional coating on hydrophobic PDMS. evaluated with fluorophore labeled antithrombin. In addition, long- Term studies revealed that the immobilized heparin was more or less stable in microchannels over a time of three weeks.",

keywords = "Biocompatible, Heparin, PDMS, Surface modification",

author = "S. Thorslund and J. Sanchez and R. Larsson and F. Nikolajeff and J. Bergquist",

year = "2005",

language = "English",

isbn = "0974361119",

volume = "1",

pages = "1270--1272",

booktitle = "Micro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference: 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences",

publisher = "Transducer Research Foundation",

note = "9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2005 ; Conference date: 09-10-2005 Through 13-10-2005",

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Thorslund, S, Sanchez, J, Larsson, R, Nikolajeff, F & Bergquist, J 2005, Functionality and stability of heparin immobilized onto poly (dimethylsiloxane). in Micro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference: 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences. vol. 1, Transducer Research Foundation, pp. 1270-1272, 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2005, Boston, MA, United States, 9/10/05.

Functionality and stability of heparin immobilized onto poly (dimethylsiloxane). / Thorslund, S.; Sanchez, J.; Larsson, R. et al.
Micro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference: 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Vol. 1 Transducer Research Foundation, 2005. p. 1270-1272.

Research output: Chapter in Book/Report/Conference proceeding › Conference proceeding contribution › peer-review

TY - GEN

T1 - Functionality and stability of heparin immobilized onto poly (dimethylsiloxane)

AU - Thorslund, S.

AU - Sanchez, J.

AU - Larsson, R.

AU - Nikolajeff, F.

AU - Bergquist, J.

PY - 2005

Y1 - 2005

N2 - We demonstrate a new grade of non-covalent heparin surface that adds efficient anticoagulant property to the poly(dimethylsiloxane) (PDMS) material. The surface modification is a simple and fast one-step process performed at neutral pH, optimal when working with closed microsystems. The heparin formed a uniform and functional coating on hydrophobic PDMS. evaluated with fluorophore labeled antithrombin. In addition, long- Term studies revealed that the immobilized heparin was more or less stable in microchannels over a time of three weeks.

AB - We demonstrate a new grade of non-covalent heparin surface that adds efficient anticoagulant property to the poly(dimethylsiloxane) (PDMS) material. The surface modification is a simple and fast one-step process performed at neutral pH, optimal when working with closed microsystems. The heparin formed a uniform and functional coating on hydrophobic PDMS. evaluated with fluorophore labeled antithrombin. In addition, long- Term studies revealed that the immobilized heparin was more or less stable in microchannels over a time of three weeks.

KW - Biocompatible

KW - Heparin

KW - PDMS

KW - Surface modification

UR - https://www.scopus.com/pages/publications/84902439120

M3 - Conference proceeding contribution

AN - SCOPUS:84902439120

SN - 0974361119

SN - 9780974361116

VL - 1

SP - 1270

EP - 1272

BT - Micro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference: 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences

PB - Transducer Research Foundation

T2 - 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2005

Y2 - 9 October 2005 through 13 October 2005

ER -

Functionality and stability of heparin immobilized onto poly (dimethylsiloxane)

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