Fungal-contaminated grass and well water and sporadic amyotrophic lateral sclerosis

Peter William French, Russell Ian Ludowyke, Gilles J. Guillemin

Research output: Contribution to journalReview articleResearchpeer-review

Abstract

Fungi are important infectious disease-causing agents, but are often overlooked as environmental factors in disease. We review several lines of evidence that point to a potential fungal origin of sporadic amyotrophic lateral sclerosis (ALS), the most common form of motor neurone disease. Approximately 90% cases of ALS are sporadic, and the aetiology of sporadic ALS is still unknown. We have previously postulated that grass or soil-associated fungal infections may be a leading cause of sporadic ALS. Herein we extend this proposal to water-associated fungi. A wide variety of fungi have been reported in drinking water including Acremonium, Alternaria, Aspergillus, Cladosporium, Fusarium, Penicillium and Trichoderma. Some of these are known to produce neurotoxic mycotoxins. Despite this, drinking water is not routinely monitored for fungal contamination. Fungal contamination could explain the close correlation between distribution of well water and cases of sporadic ALS in the United States. We propose several mechanisms by which an opportunistic fungal infection from environmental exposure (to water, soil or plants) can lead to long term neuronal degradation resulting in the hallmarks of ALS. If confirmed, the association between fungal infection and sporadic ALS could lead to novel treatment strategies for this progressive and fatal disease.

LanguageEnglish
Pages1490-1493
Number of pages4
JournalNeural Regeneration Research
Volume14
Issue number9
Early online date9 May 2019
DOIs
Publication statusPublished - 1 Sep 2019

Fingerprint

Poaceae
Mycoses
Water
Fungi
Drinking Water
Soil
Acremonium
Cladosporium
Alternaria
Motor Neuron Disease
Trichoderma
Mycotoxins
Penicillium
Opportunistic Infections
Environmental Exposure
Fusarium
Amyotrophic Lateral Sclerosis
Aspergillus
Communicable Diseases
Amyotrophic lateral sclerosis 1

Bibliographical note

Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

  • ALS
  • amyotrophic lateral sclerosis
  • fungi
  • motor neurone disease
  • mycotoxins
  • neurotoxins
  • sporadic ALS
  • well water

Cite this

French, Peter William ; Ludowyke, Russell Ian ; Guillemin, Gilles J. / Fungal-contaminated grass and well water and sporadic amyotrophic lateral sclerosis. In: Neural Regeneration Research. 2019 ; Vol. 14, No. 9. pp. 1490-1493.
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Fungal-contaminated grass and well water and sporadic amyotrophic lateral sclerosis. / French, Peter William; Ludowyke, Russell Ian; Guillemin, Gilles J.

In: Neural Regeneration Research, Vol. 14, No. 9, 01.09.2019, p. 1490-1493.

Research output: Contribution to journalReview articleResearchpeer-review

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