Fungal duel between Penicillium brasilianum and Aspergillus nomius results in dual induction of miktospiromide A and kitrinomycin A

Michael S. Cowled, John A. Kalaitzis, Andrew Crombie, Rachel Chen, Nicolau Sbaraini, Ernest Lacey, Andrew M. Piggott*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Cocultivation of the fungi Penicillium brasilianum MST-FP1927 and Aspergillus nomius MST-FP2004 resulted in the reciprocal induction of two new compounds, miktospiromide A (1) from A. nomius and kitrinomycin A (2) from P. brasilianum. A third new compound, kitrinomycin B (3), was also identified from an axenic culture of P. brasilianum, along with the previously reported compounds austalide K (4), 17S-dihydroaustalide K (5), verruculogen (6), and fumitremorgin B (7). The structures of 1-3 were elucidated by detailed spectroscopic analysis and DFT calculations, while 4-7 were identified by comparison to authentic standards. The genome of A. nomius MST-FP2004 was sequenced, and a putative biosynthetic gene cluster for 1 was identified. Compound 2 showed activity against murine melanoma NS-1 cells (LD99 7.8 μM) and the bovine parasite Tritrichomonas foetus (LD99 4.8 μM).

Original languageEnglish
Pages (from-to)2398–2406
Number of pages9
JournalJournal of Natural Products
Volume86
Issue number10
Early online date22 Sept 2023
DOIs
Publication statusPublished - 27 Oct 2023

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