FUTURE-AI: international consensus guideline for trustworthy and deployable artificial intelligence in healthcare

Karim Lekadir*, Alejandro F. Frangi, Antonio R. Porras, Ben Glocker, Celia Cintas, Curtis P. Langlotz, Eva Weicken, Folkert W. Asselbergs, Fred Prior, Gary S. Collins, Georgios Kaissis, Gianna Tsakou, Irène Buvat, Jayashree Kalpathy-Cramer, John Mongan, Julia A. Schnabel, Kaisar Kushibar, Katrine Riklund, Kostas Marias, Lameck M. AmugongoLauren A. Fromont, Lena Maier-Hein, Leonor Cerdá-Alberich, Luis Martí-Bonmatí, M. Jorge Cardoso, Maciej Bobowicz, Mahsa Shabani, Manolis Tsiknakis, Maria A. Zuluaga, Marie Christine Fritzsche, Marina Camacho, Marius George Linguraru, Markus Wenzel, Marleen De Bruijne, Martin G. Tolsgaard, Melanie Goisauf, Mónica Cano Abadía, Nikolaos Papanikolaou, Noussair Lazrak, Oriol Pujol, Richard Osuala, Sandy Napel, Sara Colantonio, Smriti Joshi, Stefan Klein, Susanna Aussó, Wendy A. Rogers, Zohaib Salahuddin, Martijn P.A. Starmans, The FUTURE-AI Consortium

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)
26 Downloads (Pure)

Abstract

Despite major advances in artificial intelligence (AI) research for healthcare, the deployment and adoption of AI technologies remain limited in clinical practice. This paper describes the FUTURE-AI framework, which provides guidance for the development and deployment of trustworthy AI tools in healthcare. The FUTURE-AI Consortium was founded in 2021 and comprises 117 interdisciplinary experts from 50 countries representing all continents, including AI scientists, clinical researchers, biomedical ethicists, and social scientists. Over a two year period, the FUTURE-AI guideline was established through consensus based on six guiding principles-fairness, universality, traceability, usability, robustness, and explainability. To operationalise trustworthy AI in healthcare, a set of 30 best practices were defined, addressing technical, clinical, socioethical, and legal dimensions. The recommendations cover the entire lifecycle of healthcare AI, from design, development, and validation to regulation, deployment, and monitoring.

Original languageEnglish
Article numbere081554
Pages (from-to)1-22
Number of pages22
JournalBMJ
Volume388
DOIs
Publication statusPublished - 5 Feb 2025

Bibliographical note

Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Article correction: In this paper by Lekadir and colleagues (BMJ 2025;388:e081554, doi:10.1136/bmj-2024-081554, published 5 February 2025), the FUTURE-AI Consortium author name “Henry C Woodruff” was spelt incorrectly in the submitted manuscript. This has since been corrected in the article and PDF.

Cite this