Gabapentin in the management of dysautonomia following severe traumatic brain injury: A case series

Ian J. Baguley*, Roxana E. Heriseanu, Joseph A. Gurka, Annette Nordenbo, Ian D. Cameron

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

77 Citations (Scopus)

Abstract

The pharmacological management of dysautonomia, otherwise known as autonomic storms, following acute neurological insults, is problematic and remains poorly researched. This paper presents six subjects with dysautonomia following extremely severe traumatic brain injury where gabapentin controlled paroxysmal autonomic changes and posturing in the early post-acute phase following limited success with conventional medication regimens. In two subjects, other medications were reduced or ceased without a recurrence of symptoms. It is proposed that medications that can block or minimise abnormal afferent stimuli may represent a better option for dysautonomia management than drugs which increase inhibition of efferent pathways. Potential mechanisms for these effects are discussed.

Original languageEnglish
Pages (from-to)539-541
Number of pages3
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume78
Issue number5
DOIs
Publication statusPublished - May 2007
Externally publishedYes

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