Gallium-67 uptake in histological variants of non-Hodgkin's lymphoma -A correlative study

Basit Iqbal*, Geoffrey M. Currie, Humayun Bashir, Uzma Afzal, M. Khalid Nawaz, Samina Mansoor, Janelle M. Wheat, Muhammad Numair Younis

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    2 Citations (Scopus)

    Abstract

    Introduction: The malignant lymphomas are the fifth most common neoplasm in both men and women. Staging, re-staging and treatment response evaluation pose a difficult task in many patients of lymphomas. Histological variants in both Hodgkin's and Non-Hodgkin's types of lymphoma greatly affect the response to treatment and overall prognosis. Objective: This study was conducted to correlate the degree of abnormal Gallium-67 uptake with the histological variants of non-Hodgkin's lymphoma. This project was a part of the study to see the ability of Gallium-67 scintigraphy to predict the response to chemotherapy early in the course of therapy. Material & Methods: 65 patients were included in the study with a mean age of 25 years. All patients had undergone medical imaging, bone marrow biopsy and histopathology. Results: Sixty-five patients were classified according to the REAL classification. 11 patients were of T-cell type, 50 were of B-cell type and 4 were anaplastic. 46 showed gallium-67 uptake in the lesions, whereas 19 (29.2%) had no discernable Gallium-67 uptake. Conclusion: There was no correlation between histological sub-types and Gallium-67 uptake in all sub-types of NHL.

    Original languageEnglish
    Pages (from-to)1-4
    Number of pages4
    JournalOpen Nuclear Medicine Journal
    Volume4
    DOIs
    Publication statusPublished - 2012

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