Gallium scanning in the management of mediastinal Hodgkin's disease

B. R. Wylie; A. E. Southee; D. E. Joshua; A. F. McLaughlin; J. Gibson; B. F. Hutton; J. G. Morris; H. Kronenberg

doi:10.1111/j.1600-0609.1989.tb01223.x

Gallium scanning in the management of mediastinal Hodgkin's disease

B. R. Wylie, A. E. Southee, D. E. Joshua^*, A. F. McLaughlin, J. Gibson, B. F. Hutton, J. G. Morris, H. Kronenberg

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

57 Citations (Scopus)

Abstract

Gallium‐67 scanning was performed pre‐ and post‐therapy in 25 patients with Hodgkin's disease and a mediastinal mass. At restaging after therapy, radiographs (or CT scans) did not predict the presence of active disease whereas gallium scans did with a high degree of accuracy. Gallium‐67 determined disease activity in those patients who had a residual mediastinal mass predicting outcome in 11 out of 12 patients; one had a late relapse at 7 years. In patients without a residual mass gallium scanning was again accurate, predicting outcome in 11 of 13 patients. Two patients with negative gallium scans but subsequent active disease were scanned too soon after chemotherapy. The results suggest that gallium scanning has an important role in the mangement of mediastinal Hodgkin's disease and is superior to all current methods of assessing disease activity irrespective of the presence of a residual mediastinal mass.

Original language	English
Pages (from-to)	344-347
Number of pages	4
Journal	European Journal of Haematology
Volume	42
Issue number	4
DOIs	https://doi.org/10.1111/j.1600-0609.1989.tb01223.x
Publication status	Published - 1989
Externally published	Yes

Keywords

gallium scanning
Hodgkin's disease
mediastinal

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10.1111/j.1600-0609.1989.tb01223.x

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title = "Gallium scanning in the management of mediastinal Hodgkin's disease",

abstract = "Gallium‐67 scanning was performed pre‐ and post‐therapy in 25 patients with Hodgkin's disease and a mediastinal mass. At restaging after therapy, radiographs (or CT scans) did not predict the presence of active disease whereas gallium scans did with a high degree of accuracy. Gallium‐67 determined disease activity in those patients who had a residual mediastinal mass predicting outcome in 11 out of 12 patients; one had a late relapse at 7 years. In patients without a residual mass gallium scanning was again accurate, predicting outcome in 11 of 13 patients. Two patients with negative gallium scans but subsequent active disease were scanned too soon after chemotherapy. The results suggest that gallium scanning has an important role in the mangement of mediastinal Hodgkin's disease and is superior to all current methods of assessing disease activity irrespective of the presence of a residual mediastinal mass.",

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author = "Wylie, {B. R.} and Southee, {A. E.} and Joshua, {D. E.} and McLaughlin, {A. F.} and J. Gibson and Hutton, {B. F.} and Morris, {J. G.} and H. Kronenberg",

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AU - Wylie, B. R.

AU - Southee, A. E.

AU - Joshua, D. E.

AU - McLaughlin, A. F.

AU - Gibson, J.

AU - Hutton, B. F.

AU - Morris, J. G.

AU - Kronenberg, H.

PY - 1989

Y1 - 1989

N2 - Gallium‐67 scanning was performed pre‐ and post‐therapy in 25 patients with Hodgkin's disease and a mediastinal mass. At restaging after therapy, radiographs (or CT scans) did not predict the presence of active disease whereas gallium scans did with a high degree of accuracy. Gallium‐67 determined disease activity in those patients who had a residual mediastinal mass predicting outcome in 11 out of 12 patients; one had a late relapse at 7 years. In patients without a residual mass gallium scanning was again accurate, predicting outcome in 11 of 13 patients. Two patients with negative gallium scans but subsequent active disease were scanned too soon after chemotherapy. The results suggest that gallium scanning has an important role in the mangement of mediastinal Hodgkin's disease and is superior to all current methods of assessing disease activity irrespective of the presence of a residual mediastinal mass.

AB - Gallium‐67 scanning was performed pre‐ and post‐therapy in 25 patients with Hodgkin's disease and a mediastinal mass. At restaging after therapy, radiographs (or CT scans) did not predict the presence of active disease whereas gallium scans did with a high degree of accuracy. Gallium‐67 determined disease activity in those patients who had a residual mediastinal mass predicting outcome in 11 out of 12 patients; one had a late relapse at 7 years. In patients without a residual mass gallium scanning was again accurate, predicting outcome in 11 of 13 patients. Two patients with negative gallium scans but subsequent active disease were scanned too soon after chemotherapy. The results suggest that gallium scanning has an important role in the mangement of mediastinal Hodgkin's disease and is superior to all current methods of assessing disease activity irrespective of the presence of a residual mediastinal mass.

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Gallium scanning in the management of mediastinal Hodgkin's disease

Abstract

Keywords

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