Abstract
Objective: The purpose of the current study was to
look for evidence of sub-clinical inflammation along
the visual pathway and structural and functional
changes in outer retina and investigate its possible
association with RGC loss in NON-ON eyes of MS
patients.
Methods: Forty NON-ON eyes of 40 RRMS patients
and thirty controls were included. The thickness of the
retinal layers was measured by Spectralis OCT and
analysed using custom design segmentation software.
RGCs were assessed using thickness of Ganglion Cell
Complex (GCC). Structural and functional integrity of
outer retina was analysed using thickness of INL and
ORL and full-field electroretinogram (ERG), while
Multifocal Visual Evoked Potentials (mfVEP) were per-
formed to assess the sub-clinical inflammation along
the visual pathway.
Results: The thickness of GCC was significantly
reduced (80.4+/−7.9 μ vs 87.0+/−5.5 μ, p = 0.0003).
No significant change in INL or ORL was detected
(p = 0.2 and 0.06). There was also no significant change
in any of the ERG parameters. The latency of mfVEP,
however, was significantly delayed (p = 0.00001). GCC
thickness correlated significantly with latency delay of
the mfVEP (r2= 0.34, p < 0.001), but not with thick-
ness of outer retina layers or any ERG parameters.
There was no significant thinning of GCC (84.0+/−3.6 μ,
p = 0.08) in patients with normal (<99th percentile)
mfVEP latency (17 patients). However in patients with
a delayed latency (>99th percentile, 23 patients) GCC
reduction become even more apparent (78.0+/−8.9 μ,
p = 0.00005).
Conclusions: Our result demonstrates significant
association of RGCs loss with sub-clinical inflamma-
tion along the visual pathway. No evidence of primary
retinal loss was found.
look for evidence of sub-clinical inflammation along
the visual pathway and structural and functional
changes in outer retina and investigate its possible
association with RGC loss in NON-ON eyes of MS
patients.
Methods: Forty NON-ON eyes of 40 RRMS patients
and thirty controls were included. The thickness of the
retinal layers was measured by Spectralis OCT and
analysed using custom design segmentation software.
RGCs were assessed using thickness of Ganglion Cell
Complex (GCC). Structural and functional integrity of
outer retina was analysed using thickness of INL and
ORL and full-field electroretinogram (ERG), while
Multifocal Visual Evoked Potentials (mfVEP) were per-
formed to assess the sub-clinical inflammation along
the visual pathway.
Results: The thickness of GCC was significantly
reduced (80.4+/−7.9 μ vs 87.0+/−5.5 μ, p = 0.0003).
No significant change in INL or ORL was detected
(p = 0.2 and 0.06). There was also no significant change
in any of the ERG parameters. The latency of mfVEP,
however, was significantly delayed (p = 0.00001). GCC
thickness correlated significantly with latency delay of
the mfVEP (r2= 0.34, p < 0.001), but not with thick-
ness of outer retina layers or any ERG parameters.
There was no significant thinning of GCC (84.0+/−3.6 μ,
p = 0.08) in patients with normal (<99th percentile)
mfVEP latency (17 patients). However in patients with
a delayed latency (>99th percentile, 23 patients) GCC
reduction become even more apparent (78.0+/−8.9 μ,
p = 0.00005).
Conclusions: Our result demonstrates significant
association of RGCs loss with sub-clinical inflamma-
tion along the visual pathway. No evidence of primary
retinal loss was found.
Original language | English |
---|---|
Pages (from-to) | 142-142 |
Number of pages | 1 |
Journal | Clinical and Experimental Ophthalmology |
Volume | 40 |
Issue number | Supplement 1 |
Publication status | Published - Dec 2012 |