TY - JOUR
T1 - Gangliosides in the treatment of mental deterioration
T2 - A DOUBLE‐BLIND COMPARISON WITH PLACEBO
AU - Miceli, G.
AU - Caltagirone, C.
AU - Gainotti, G.
PY - 1977
Y1 - 1977
N2 - Thirty patients showing signs of mental deterioration were submitted to a neuropsychological battery before and after treatment with gangliosides. Their performances were compared, in a double‐blind study, with those obtained on the same tests by 30 patients affected by similar degrees of dementia and treated with placebo. The improvement shown on Raven's Coloured Progressive Matrices and on Immediate Visual Memory by the active group was significantly higher than that shown by the placebo group. Furthermore, an evaluation of the overall effect of gangliosides therapy showed a highly significant difference between the active and placebo group, still in favour of the subjects treated with gangliosides. It is concluded that gangliosides may exert a positive effect in the treatment of demential syndromes.
AB - Thirty patients showing signs of mental deterioration were submitted to a neuropsychological battery before and after treatment with gangliosides. Their performances were compared, in a double‐blind study, with those obtained on the same tests by 30 patients affected by similar degrees of dementia and treated with placebo. The improvement shown on Raven's Coloured Progressive Matrices and on Immediate Visual Memory by the active group was significantly higher than that shown by the placebo group. Furthermore, an evaluation of the overall effect of gangliosides therapy showed a highly significant difference between the active and placebo group, still in favour of the subjects treated with gangliosides. It is concluded that gangliosides may exert a positive effect in the treatment of demential syndromes.
KW - Gangliosides therapy
KW - mental deterioration
KW - neuropsychological tests
UR - http://www.scopus.com/inward/record.url?scp=0017618106&partnerID=8YFLogxK
U2 - 10.1111/j.1600-0447.1977.tb00145.x
DO - 10.1111/j.1600-0447.1977.tb00145.x
M3 - Article
C2 - 320829
AN - SCOPUS:0017618106
SN - 0001-690X
VL - 55
SP - 102
EP - 110
JO - Acta Psychiatrica Scandinavica
JF - Acta Psychiatrica Scandinavica
IS - 2
ER -