Generation of VCCRIi001-A, a human induced pluripotent stem cell line, from a patient with spontaneous coronary artery dissection

Ketan Mishra; Keerat Junday; Claire M. Y. Wong; Andrea Y. Chan; Stephanie Hesselson; David W. Muller; Siiri E. Iismaa; Ashish Mehta; Robert M. Graham

doi:10.1016/j.scr.2019.101584

Generation of VCCRIi001-A, a human induced pluripotent stem cell line, from a patient with spontaneous coronary artery dissection

Ketan Mishra, Keerat Junday, Claire M. Y. Wong, Andrea Y. Chan, Stephanie Hesselson, David W. Muller, Siiri E. Iismaa, Ashish Mehta, Robert M. Graham

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

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Abstract

Spontaneous coronary artery dissection (SCAD) is a non-atherosclerotic form of coronary artery disease of unknown cause that predominantly affects women (>90%; mean age 44-55 years) and can be fatal. The finding of familial clustering, including the concordant involvement of monozygotic twins, and its association with the PHACTR1/EDN1 genetic locus, indicate a genetic predisposition to its pathophysiology. A human induced pluripotent stem cell line (hiPSC) was generated from a patient who had survived an episode of SCAD. This disease-specific hiPSC line will be useful for the study of SCAD after differentiation into blood vessel-forming cells.

Original language	English
Article number	101584
Pages (from-to)	1-4
Number of pages	4
Journal	Stem Cell Research
Volume	41
DOIs	https://doi.org/10.1016/j.scr.2019.101584
Publication status	Published - Dec 2019
Externally published	Yes

Bibliographical note

Copyright the Author(s) 2019. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

SCAD
Induced pluripotent stem cells
Disease modeling
Cardiovascular biology
Reprogramming

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10.1016/j.scr.2019.101584

Publisher version (open access)Final published version, 1.21 MBLicence: CC BY-NC-ND

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title = "Generation of VCCRIi001-A, a human induced pluripotent stem cell line, from a patient with spontaneous coronary artery dissection",

abstract = "Spontaneous coronary artery dissection (SCAD) is a non-atherosclerotic form of coronary artery disease of unknown cause that predominantly affects women (>90%; mean age 44-55 years) and can be fatal. The finding of familial clustering, including the concordant involvement of monozygotic twins, and its association with the PHACTR1/EDN1 genetic locus, indicate a genetic predisposition to its pathophysiology. A human induced pluripotent stem cell line (hiPSC) was generated from a patient who had survived an episode of SCAD. This disease-specific hiPSC line will be useful for the study of SCAD after differentiation into blood vessel-forming cells.",

keywords = "SCAD, Induced pluripotent stem cells, Disease modeling, Cardiovascular biology, Reprogramming",

author = "Ketan Mishra and Keerat Junday and Wong, {Claire M. Y.} and Chan, {Andrea Y.} and Stephanie Hesselson and Muller, {David W.} and Iismaa, {Siiri E.} and Ashish Mehta and Graham, {Robert M.}",

note = "Copyright the Author(s) 2019. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.",

year = "2019",

month = dec,

doi = "10.1016/j.scr.2019.101584",

language = "English",

volume = "41",

pages = "1--4",

journal = "Stem Cell Research",

issn = "1873-5061",

publisher = "Elsevier",

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Generation of VCCRIi001-A, a human induced pluripotent stem cell line, from a patient with spontaneous coronary artery dissection. / Mishra, Ketan; Junday, Keerat; Wong, Claire M. Y.; Chan, Andrea Y.; Hesselson, Stephanie; Muller, David W.; Iismaa, Siiri E.; Mehta, Ashish; Graham, Robert M.

In: Stem Cell Research, Vol. 41, 101584, 12.2019, p. 1-4.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Generation of VCCRIi001-A, a human induced pluripotent stem cell line, from a patient with spontaneous coronary artery dissection

AU - Mishra, Ketan

AU - Junday, Keerat

AU - Wong, Claire M. Y.

AU - Chan, Andrea Y.

AU - Hesselson, Stephanie

AU - Muller, David W.

AU - Iismaa, Siiri E.

AU - Mehta, Ashish

AU - Graham, Robert M.

N1 - Copyright the Author(s) 2019. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

PY - 2019/12

Y1 - 2019/12

N2 - Spontaneous coronary artery dissection (SCAD) is a non-atherosclerotic form of coronary artery disease of unknown cause that predominantly affects women (>90%; mean age 44-55 years) and can be fatal. The finding of familial clustering, including the concordant involvement of monozygotic twins, and its association with the PHACTR1/EDN1 genetic locus, indicate a genetic predisposition to its pathophysiology. A human induced pluripotent stem cell line (hiPSC) was generated from a patient who had survived an episode of SCAD. This disease-specific hiPSC line will be useful for the study of SCAD after differentiation into blood vessel-forming cells.

AB - Spontaneous coronary artery dissection (SCAD) is a non-atherosclerotic form of coronary artery disease of unknown cause that predominantly affects women (>90%; mean age 44-55 years) and can be fatal. The finding of familial clustering, including the concordant involvement of monozygotic twins, and its association with the PHACTR1/EDN1 genetic locus, indicate a genetic predisposition to its pathophysiology. A human induced pluripotent stem cell line (hiPSC) was generated from a patient who had survived an episode of SCAD. This disease-specific hiPSC line will be useful for the study of SCAD after differentiation into blood vessel-forming cells.

KW - SCAD

KW - Induced pluripotent stem cells

KW - Disease modeling

KW - Cardiovascular biology

KW - Reprogramming

UR - http://purl.org/au-research/grants/nhmrc/1161200

UR - http://www.scopus.com/inward/record.url?scp=85074464969&partnerID=8YFLogxK

U2 - 10.1016/j.scr.2019.101584

DO - 10.1016/j.scr.2019.101584

M3 - Article

C2 - 31707208

VL - 41

SP - 1

EP - 4

JO - Stem Cell Research

JF - Stem Cell Research

SN - 1873-5061

M1 - 101584

ER -

Generation of VCCRIi001-A, a human induced pluripotent stem cell line, from a patient with spontaneous coronary artery dissection

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