Generation of VCCRIi001-A, a human induced pluripotent stem cell line, from a patient with spontaneous coronary artery dissection

Ketan Mishra, Keerat Junday, Claire M. Y. Wong, Andrea Y. Chan, Stephanie Hesselson, David W. Muller, Siiri E. Iismaa, Ashish Mehta, Robert M. Graham

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Abstract

Spontaneous coronary artery dissection (SCAD) is a non-atherosclerotic form of coronary artery disease of unknown cause that predominantly affects women (>90%; mean age 44-55 years) and can be fatal. The finding of familial clustering, including the concordant involvement of monozygotic twins, and its association with the PHACTR1/EDN1 genetic locus, indicate a genetic predisposition to its pathophysiology. A human induced pluripotent stem cell line (hiPSC) was generated from a patient who had survived an episode of SCAD. This disease-specific hiPSC line will be useful for the study of SCAD after differentiation into blood vessel-forming cells.

Original languageEnglish
Article number101584
Pages (from-to)1-4
Number of pages4
JournalStem Cell Research
Volume41
DOIs
Publication statusPublished - Dec 2019
Externally publishedYes

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Bibliographical note

Copyright the Author(s) 2019. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

  • SCAD
  • Induced pluripotent stem cells
  • Disease modeling
  • Cardiovascular biology
  • Reprogramming

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