Genetic and environmental factors in vascular dementia: an update of blood brain barrier dysfunction

Vivek Srinivasan, Nady Braidy, Eunice K.W. Chan, Ying Hua Xu, Daniel K.Y. Chan*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Vascular dementia (VaD) describes a combination of both cognitive and behavioural manifestations associated with variable brain lesions of vascular origin. While vascular risk factors have been implicated in VaD, the relationship is most evident when the factors are considered together and not individually. This review will examine the significance of the integrity of blood brain barrier (BBB) tight junction (TJ) proteins - occludin and claudins in the pathophysiology of VaD. Specifically, some of the genetic contributors to VaD, namely those responsible for the integrity of the BBB, will be reviewed in detail. Moreover, environmental factors will be considered in conjunction with these genes to examine how the interaction of environmental and genetic factors contributes to one's susceptibility to VaD.

Original languageEnglish
Pages (from-to)515-521
Number of pages7
JournalClinical and Experimental Pharmacology and Physiology
Volume43
Issue number5
DOIs
Publication statusPublished - 1 May 2016
Externally publishedYes

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