Genetic basis of histocompatibility in the solitary urochordate Styela plicata

D. A. Raftos*, D. A. Briscoe

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Comparative tissue typing was used to demonstrate the monofactorial inheritance of alloantigenicity in the solitary urochordate Styela plicata. Analysis of rejection patterns in reciprocal allografting matrices allowed the identification of a number of homozygous individuals. Selected homozygotes were then used as donors to define the histocompatibility genotypes of naive individuals. Using this method, five discrete tissue haplotypes were identified in the Balmoral Beach population of S. plicata. Such limited polymorphism of histocompatibility is inconsistent with polyfactorial inheritance. Moreover, analysis of genotype frequencies supported the hypothesis that alloantigenicity is encoded by a single genetic locus. These results support the existence of discretely encoded histocompatibility antigens in S. plicata.

Original languageEnglish
Pages (from-to)96-100
Number of pages5
JournalJournal of Heredity
Volume81
Issue number2
Publication statusPublished - Mar 1990

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