Genetic correlation between cortical gray matter thickness and white matter connections

Kaikai Shen*, Vincent Dore, Jurgen Fripp, Stephen Rose, Katie L. McMahon, Greig I. de Zubicaray, Nicholas G. Martin, Paul M. Thompson, Margaret J. Wright, Olivier Salvado

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

The aim of this paper is to investigate the common genetic influence on the cortical thickness (CT) and white matter (WM) connectivity. To this aim, we analyzed cortical gray matter (GM) thickness derived from structural magnetic resonance images and the measures of WM connected to the cortex obtained from diffusion magnetic resonance imaging (dMRI) on a large twin imaging cohort (N = 308, average age 22.8 ± 2.3 SD). The CT was estimated using a surface-based approach, and the WM connections were measured based on probabilistic tractography using fiber orientation distributions (FODs) from dMRI. Bivariate genetic modeling was performed on CT and FOD measure of tracts connected to the cortex. Significant genetic correlations between the CT and WM connectivity were found in regions, including the right postcentral gyrus, left posterior cingulated gyrus, right dorsolateral superior frontal gyrus, the right middle, and inferior temporal gyri, suggesting common genetic factors influencing the GM and WM.

Original languageEnglish
Title of host publicationImaging genetics
EditorsAdrian V. Dalca, Nematollah K. Batmanghelich, Li Shen, Mert R. Sabuncu
PublisherACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
Pages85-100
Number of pages16
ISBN (Electronic)9780128139691
ISBN (Print)9780128139684
DOIs
Publication statusPublished - 2018
Externally publishedYes

Publication series

NameElsevier and MICCAI Society Book Series
PublisherACADEMIC PRESS LTD-ELSEVIER SCIENCE LTD

Keywords

  • Cortical thickness
  • Diffusion MRI
  • Genetic correlation
  • Gray matter
  • Structural MRI
  • White matter connectivity

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