TY - JOUR
T1 - Genetic discoveries in hypertension
T2 - Steps on the road to therapeutic translation
AU - Lind, Joanne Maree
AU - Chiu, Christine Laiwan
PY - 2013/11
Y1 - 2013/11
N2 - Genes and environmental factors contribute to an individual's risk of hypertension. Recent advances in DNA sequencing technology have enabled the discovery of new causative genes in inherited forms of hypertension, identifying novel pathways for blood pressure control. Meta-analyses of genome-wide association studies have also identified regions of the genome that are significantly associated with blood pressure control, and these regions may be involved in an individual's response to antihypertensive medication. This article reviews the latest gene discoveries in inherited forms of hypertension, recent meta-analyses of genome-wide association studies, genetic determinants of antihypertensive therapy response, and development of genetic risk scores.
AB - Genes and environmental factors contribute to an individual's risk of hypertension. Recent advances in DNA sequencing technology have enabled the discovery of new causative genes in inherited forms of hypertension, identifying novel pathways for blood pressure control. Meta-analyses of genome-wide association studies have also identified regions of the genome that are significantly associated with blood pressure control, and these regions may be involved in an individual's response to antihypertensive medication. This article reviews the latest gene discoveries in inherited forms of hypertension, recent meta-analyses of genome-wide association studies, genetic determinants of antihypertensive therapy response, and development of genetic risk scores.
UR - http://www.scopus.com/inward/record.url?scp=84885861263&partnerID=8YFLogxK
U2 - 10.1136/heartjnl-2012-302883
DO - 10.1136/heartjnl-2012-302883
M3 - Article
C2 - 23474626
AN - SCOPUS:84885861263
SN - 1355-6037
VL - 99
SP - 1645
EP - 1651
JO - Heart
JF - Heart
IS - 22
ER -