Genetically modified ruminal bacteria protect sheep from fluoroacetate poisoning

Keith Gregg*, Brenton Hamdorf, Kerrin Henderson, Jan Kopecny, Cheryl Wong

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

86 Citations (Scopus)


Four strains of Butyrivibrio fibrisolvens, transformed with a gene encoding fluoroacetate dehalogenase, maintained a combined population of 106 to 107 cells ml-1 in the rumens of test sheep. Five inoculated sheep showed markedly reduced toxicological symptoms after fluoroacetate poisoning when behavioral, physiological, and histological effects were compared with those of five uninoculated control sheep.

Original languageEnglish
Pages (from-to)3496-3498
Number of pages3
JournalApplied and Environmental Microbiology
Issue number9
Publication statusPublished - 1998
Externally publishedYes


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