Genetics of age-related hearing loss

Piers Dawes*, Antony Payton

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

5 Citations (Scopus)


Age-related hearing loss (ARHL) is a complex multifactorial disease. It is highly prevalent in older adults and has significant adverse impact on communication, mental health and quality of life. Severity and onset of ARHL varies substantially between individuals, and heritability estimates of ARHL range up to 75%. Understanding the genetics of ARHL may allow targeted treatment or prevention. We review the current research in humans on genetic susceptibility to ARHL related to (1) cell adhesion, cell shape and epithelial development, (2) neurotransmission, (3) oxidative stress, (4) immune response/apoptosis, and (5) other functions.

Original languageEnglish
Title of host publicationGenetics of deafness
EditorsBarbara Vona, Thomas Haaf
Place of PublicationBasel ; New York
Number of pages13
ISBN (Electronic)9783318058567
ISBN (Print)9783318058550
Publication statusPublished - 2016
Externally publishedYes

Publication series

NameMonographs in human genetics
PublisherS. Karger AG
ISSN (Print)0077-0876
ISSN (Electronic)1662–3835


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