Genome-guided discovery of natural products and biosynthetic pathways from Australia's untapped microbial megadiversity

John A. Kalaitzis, Shane D. Ingrey, Rocky Chau, Yvette Simon, Brett A. Neilan*

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Historically microbial natural product biosynthesis pathways were elucidated mainly by isotope labelled precursor directed feeding studies. Now the genetics underpinning the assembly of microbial natural products biosynthesis is so well understood that some pathways and their products can be predicted from DNA sequences alone. The association between microbial natural products and their biosynthesis gene clusters is now driving the field of 'genetics guided natural product discovery'. This account overviews our research into cyanotoxin biosynthesis before the genome sequencing era through to some recent discoveries resulting from the mining of Australian biota for natural product biosynthesis pathways.

Original languageEnglish
Pages (from-to)129-135
Number of pages7
JournalAustralian Journal of Chemistry
Volume69
Issue number2
DOIs
Publication statusPublished - 2016
Externally publishedYes

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