Genome of an octopus-derived Pseudoalteromonas reveals unprecedented natural product biosynthesis gene clusters

R. Chau, J. A. Kalaitzis, B. A. Neilan

Research output: Contribution to journalMeeting abstract

Abstract

The highly toxic octopus species Hapalochlaena maculosa is home to a diverse community of microorganisms, some of which are proposed to give rise to small natural products involved in life-sustaining processes such as chemical defence or signalling. The H. maculosa derived bacterial isolate Pseudoalteromonas sp. HM-SA03 was selected for genome sequencing on the basis of its biosynthetic potential as indicated by targeted PCR.

Genome mining of the draft sequence revealed 6 hybrid NPRS-PKS coding biosynthesis gene clusters which display little homology to known clusters. Partial characterisation of these clusters using bioinformatics techniques has allowed structures of these NRPS/PKS products to be predicted. Here we present the complement of NRPS-PKS gene clusters and report on the discovery of some compounds from Pseudoalteromonas sp. HM-SA03.
Original languageEnglish
Article numberCL53
JournalPlanta Medica
Volume78
Issue number11
DOIs
Publication statusPublished - 2012
EventInternational Congress on Natural Products Research: 8th Joint Meeting of AFERP, ASP, GA, PSE and SIF - New York, New York, United States
Duration: 28 Jul 20121 Aug 2012

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