Genome of the human hookworm Necator americanus

Yat T. Tang; Xin Gao; Bruce A. Rosa; Sahar Abubucker; Kymberlie Hallsworth-Pepin; John Martin; Rahul Tyagi; Esley Heizer; Xu Zhang; Veena Bhonagiri-Palsikar; Patrick Minx; Wesley C. Warren; Qi Wang; Bin Zhan; Peter J. Hotez; Paul W. Sternberg; Annette Dougall; Soraya Torres Gaze; Jason Mulvenna; Javier Sotillo; Shoba Ranganathan; Elida M. Rabelo; Richard K. Wilson; Philip L. Felgner; Jeffrey Bethony; John M. Hawdon; Robin B. Gasser; Alex Loukas; Makedonka Mitreva

doi:10.1038/ng.2875

Genome of the human hookworm Necator americanus

Yat T. Tang, Xin Gao, Bruce A. Rosa, Sahar Abubucker, Kymberlie Hallsworth-Pepin, John Martin, Rahul Tyagi, Esley Heizer, Xu Zhang, Veena Bhonagiri-Palsikar, Patrick Minx, Wesley C. Warren, Qi Wang, Bin Zhan, Peter J. Hotez, Paul W. Sternberg, Annette Dougall, Soraya Torres Gaze, Jason Mulvenna, Javier SotilloShoba Ranganathan, Elida M. Rabelo, Richard K. Wilson, Philip L. Felgner, Jeffrey Bethony, John M. Hawdon, Robin B. Gasser, Alex Loukas, Makedonka Mitreva^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

The hookworm Necator americanus is the predominant soil-transmitted human parasite. Adult worms feed on blood in the small intestine, causing iron-deficiency anemia, malnutrition, growth and development stunting in children, and severe morbidity and mortality during pregnancy in women. We report sequencing and assembly of the N. americanus genome (244 Mb, 19,151 genes). Characterization of this first hookworm genome sequence identified genes orchestrating the hookworm's invasion of the human host, genes involved in blood feeding and development, and genes encoding proteins that represent new potential drug targets against hookworms. N. americanus has undergone a considerable and unique expansion of immunomodulator proteins, some of which we highlight as potential treatments against inflammatory diseases. We also used a protein microarray to demonstrate a postgenomic application of the hookworm genome sequence. This genome provides an invaluable resource to boost ongoing efforts toward fundamental and applied postgenomic research, including the development of new methods to control hookworm and human immunological diseases.

Original language	English
Pages (from-to)	261-269
Number of pages	9
Journal	Nature Genetics
Volume	46
Issue number	3
DOIs	https://doi.org/10.1038/ng.2875
Publication status	Published - Mar 2014

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Tang, Y. T., Gao, X., Rosa, B. A., Abubucker, S., Hallsworth-Pepin, K., Martin, J., Tyagi, R., Heizer, E., Zhang, X., Bhonagiri-Palsikar, V., Minx, P., Warren, W. C., Wang, Q., Zhan, B., Hotez, P. J., Sternberg, P. W., Dougall, A., Gaze, S. T., Mulvenna, J., ... Mitreva, M. (2014). Genome of the human hookworm Necator americanus. Nature Genetics, 46(3), 261-269. https://doi.org/10.1038/ng.2875

@article{651620c368144ef080230de25ba6da10,

title = "Genome of the human hookworm Necator americanus",

abstract = "The hookworm Necator americanus is the predominant soil-transmitted human parasite. Adult worms feed on blood in the small intestine, causing iron-deficiency anemia, malnutrition, growth and development stunting in children, and severe morbidity and mortality during pregnancy in women. We report sequencing and assembly of the N. americanus genome (244 Mb, 19,151 genes). Characterization of this first hookworm genome sequence identified genes orchestrating the hookworm's invasion of the human host, genes involved in blood feeding and development, and genes encoding proteins that represent new potential drug targets against hookworms. N. americanus has undergone a considerable and unique expansion of immunomodulator proteins, some of which we highlight as potential treatments against inflammatory diseases. We also used a protein microarray to demonstrate a postgenomic application of the hookworm genome sequence. This genome provides an invaluable resource to boost ongoing efforts toward fundamental and applied postgenomic research, including the development of new methods to control hookworm and human immunological diseases.",

author = "Tang, {Yat T.} and Xin Gao and Rosa, {Bruce A.} and Sahar Abubucker and Kymberlie Hallsworth-Pepin and John Martin and Rahul Tyagi and Esley Heizer and Xu Zhang and Veena Bhonagiri-Palsikar and Patrick Minx and Warren, {Wesley C.} and Qi Wang and Bin Zhan and Hotez, {Peter J.} and Sternberg, {Paul W.} and Annette Dougall and Gaze, {Soraya Torres} and Jason Mulvenna and Javier Sotillo and Shoba Ranganathan and Rabelo, {Elida M.} and Wilson, {Richard K.} and Felgner, {Philip L.} and Jeffrey Bethony and Hawdon, {John M.} and Gasser, {Robin B.} and Alex Loukas and Makedonka Mitreva",

note = "Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.",

year = "2014",

month = mar,

doi = "10.1038/ng.2875",

language = "English",

volume = "46",

pages = "261--269",

journal = "Nature Genetics",

issn = "1061-4036",

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Tang, YT, Gao, X, Rosa, BA, Abubucker, S, Hallsworth-Pepin, K, Martin, J, Tyagi, R, Heizer, E, Zhang, X, Bhonagiri-Palsikar, V, Minx, P, Warren, WC, Wang, Q, Zhan, B, Hotez, PJ, Sternberg, PW, Dougall, A, Gaze, ST, Mulvenna, J, Sotillo, J, Ranganathan, S, Rabelo, EM, Wilson, RK, Felgner, PL, Bethony, J, Hawdon, JM, Gasser, RB, Loukas, A & Mitreva, M 2014, 'Genome of the human hookworm Necator americanus', Nature Genetics, vol. 46, no. 3, pp. 261-269. https://doi.org/10.1038/ng.2875

TY - JOUR

T1 - Genome of the human hookworm Necator americanus

AU - Tang, Yat T.

AU - Gao, Xin

AU - Rosa, Bruce A.

AU - Abubucker, Sahar

AU - Hallsworth-Pepin, Kymberlie

AU - Martin, John

AU - Tyagi, Rahul

AU - Heizer, Esley

AU - Zhang, Xu

AU - Bhonagiri-Palsikar, Veena

AU - Minx, Patrick

AU - Warren, Wesley C.

AU - Wang, Qi

AU - Zhan, Bin

AU - Hotez, Peter J.

AU - Sternberg, Paul W.

AU - Dougall, Annette

AU - Gaze, Soraya Torres

AU - Mulvenna, Jason

AU - Sotillo, Javier

AU - Ranganathan, Shoba

AU - Rabelo, Elida M.

AU - Wilson, Richard K.

AU - Felgner, Philip L.

AU - Bethony, Jeffrey

AU - Hawdon, John M.

AU - Gasser, Robin B.

AU - Loukas, Alex

AU - Mitreva, Makedonka

N1 - Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

PY - 2014/3

Y1 - 2014/3

N2 - The hookworm Necator americanus is the predominant soil-transmitted human parasite. Adult worms feed on blood in the small intestine, causing iron-deficiency anemia, malnutrition, growth and development stunting in children, and severe morbidity and mortality during pregnancy in women. We report sequencing and assembly of the N. americanus genome (244 Mb, 19,151 genes). Characterization of this first hookworm genome sequence identified genes orchestrating the hookworm's invasion of the human host, genes involved in blood feeding and development, and genes encoding proteins that represent new potential drug targets against hookworms. N. americanus has undergone a considerable and unique expansion of immunomodulator proteins, some of which we highlight as potential treatments against inflammatory diseases. We also used a protein microarray to demonstrate a postgenomic application of the hookworm genome sequence. This genome provides an invaluable resource to boost ongoing efforts toward fundamental and applied postgenomic research, including the development of new methods to control hookworm and human immunological diseases.

AB - The hookworm Necator americanus is the predominant soil-transmitted human parasite. Adult worms feed on blood in the small intestine, causing iron-deficiency anemia, malnutrition, growth and development stunting in children, and severe morbidity and mortality during pregnancy in women. We report sequencing and assembly of the N. americanus genome (244 Mb, 19,151 genes). Characterization of this first hookworm genome sequence identified genes orchestrating the hookworm's invasion of the human host, genes involved in blood feeding and development, and genes encoding proteins that represent new potential drug targets against hookworms. N. americanus has undergone a considerable and unique expansion of immunomodulator proteins, some of which we highlight as potential treatments against inflammatory diseases. We also used a protein microarray to demonstrate a postgenomic application of the hookworm genome sequence. This genome provides an invaluable resource to boost ongoing efforts toward fundamental and applied postgenomic research, including the development of new methods to control hookworm and human immunological diseases.

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U2 - 10.1038/ng.2875

DO - 10.1038/ng.2875

M3 - Article

C2 - 24441737

AN - SCOPUS:84895883455

SN - 1061-4036

VL - 46

SP - 261

EP - 269

JO - Nature Genetics

JF - Nature Genetics

IS - 3

ER -

Genome of the human hookworm Necator americanus

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