Genome sequence of the cyanobacterium Prochlorococcus marinus SS120, a nearly minimal oxyphototrophic genome

Alexis Dufresne, Marcel Salanoubat, Frédéric Partensky*, François Artiguenave, Ilka M. Axmann, Valérie Barbe, Simone Duprat, Michael Y. Galperin, Eugene V. Koonin, Florence Le Gall, Kira S. Makarova, Martin Ostrowski, Sophie Oztas, Catherine Robert, Igor B. Rogozin, David J. Scanlan, Nicole Tandeau De Marsac, Jean Weissenbach, Patrick Wincker, Yuri I. Wolf & 1 others Wolfgang R. Hess

*Corresponding author for this work

Research output: Contribution to journalArticle

342 Citations (Scopus)

Abstract

Prochlorococcus marinus, the dominant photosynthetic organism in the ocean, is found in two main ecological forms: high-light-adapted genotypes in the upper part of the water column and low-light-adapted genotypes at the bottom of the illuminated layer. P. marinus SS120, the complete genome sequence reported here, is an extremely low-light-adapted form. The genome of P. marinus SS120 is composed of a single circular chromosome of 1,751,080 bp with an average G + C content of 36.4%. It contains 1,884 predicted protein-coding genes with an average size of 825 bp, a single rRNA operon, and 40 tRNA genes. Together with the 1.66-Mbp genome of P. marinus MED4, the genome of P. marinus SS120 is one of the two smallest genomes of a photosynthetic organism known to date. It lacks many genes that are involved in photosynthesis, DNA repair, solute uptake, intermediary metabolism, motility, phototaxis, and other functions that are conserved among other cyanobacteria. Systems of signal transduction and environmental stress response show a particularly drastic reduction in the number of components, even taking into account the small size of the SS120 genome. In contrast, housekeeping genes, which encode enzymes of amino acid, nucleotide, cofactor, and cell wall biosynthesis, are all present. Because of its remarkable compactness, the genome of P. marinus SS120 might approximate the minimal gene complement of a photosynthetic organism.

Original languageEnglish
Pages (from-to)10020-10025
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume100
Issue number17
DOIs
Publication statusPublished - 19 Aug 2003
Externally publishedYes

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