Genome sequence of Theileria parva, a bovine pathogen that transforms lymphocytes

Malcolm J. Gardner*, Richard Bishop, Trushar Shah, Etienne P. De Villiers, Jane M. Carlton, Neil Hall, Qinghu Ren, Ian T. Paulsen, Arnab Pain, Matthew Berriman, Robert J M Wilson, Shigeharu Sato, Stuart A. Ralph, David J. Mann, Zikai Xiong, Shamira J. Shallom, Janice Weidman, Lingxia Jiang, Jeffery Lynn, Bruce WeaverAzadeh Shoaibi, Alexander R. Domingo, Delia Wasawo, Jonathan Crabtree, Jennifer R. Wortman, Brian Haas, Samuel V. Angiuoli, Todd H. Creasy, Charles Lu, Bernard Suh, Joana C. Silva, Teresa R. Utterback, Tamara V. Feldblyum, Mihaela Pertea, Jonathan Allen, William C. Nierman, Evans L N Taracha, Steven L. Salzberg, Owen R. White, Henry A. Fitzhugh, Subhash Morzaria, J. Craig Venter, Claire M. Fraser, Vishvanath Nene

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

285 Citations (Scopus)


We report the genome sequence of Theileria parva, an apicomplexan pathogen causing economic losses to smallholder farmers in Africa. The parasite chromosomes exhibit limited conservation of gene synteny with Plasmodium falciparum, and its plastid-like genome represents the first example where all apicoplast genes are encoded on one DNA strand. We tentatively identify proteins that facilitate parasite segregation during host cell cytokinesis and contribute to persistent infection of transformed host cells. Several biosynthetic pathways are incomplete or absent, suggesting substantial metabolic dependence on the host cell. One protein family that may generate parasite antigenic diversity is not telomere-associated.

Original languageEnglish
Pages (from-to)134-137
Number of pages4
Issue number5731
Publication statusPublished - 1 Jul 2005
Externally publishedYes


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