Genomic identification of a novel mutation in hfq that provides multiple benefits in evolving glucose-limited populations of Escherichia coli

Ram Maharjan; Zhemin Zhou; Yan Ren; Yang Li; Joël Gaffé; Dominique Schneider; Christopher McKenzie; Peter R. Reeves; Thomas Ferenci; Lei Wang

doi:10.1128/JB.00368-10

Genomic identification of a novel mutation in hfq that provides multiple benefits in evolving glucose-limited populations of Escherichia coli

Ram Maharjan, Zhemin Zhou, Yan Ren, Yang Li, Joël Gaffé, Dominique Schneider, Christopher McKenzie, Peter R. Reeves, Thomas Ferenci, Lei Wang

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

Beneficial mutations in diversifying glucose-limited Escherichia coli populations are mostly unidentified. The genome of an evolved isolate with multiple differences from that of the ancestor was fully assembled. Remarkably, a single mutation in hfq was responsible for the multiple benefits under glucose limitation through changes in at least five regulation targets.

Original language	English
Pages (from-to)	4517-4521
Number of pages	5
Journal	Journal of Bacteriology
Volume	192
Issue number	17
DOIs	https://doi.org/10.1128/JB.00368-10
Publication status	Published - Sept 2010
Externally published	Yes

Keywords

Adaptation, Physiological
Escherichia coli/genetics
Escherichia coli Proteins/genetics
Evolution, Molecular
Gene Expression Regulation, Bacterial
Genome, Bacterial
Glucose/metabolism
Host Factor 1 Protein/genetics
Mutation

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10.1128/JB.00368-10

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title = "Genomic identification of a novel mutation in hfq that provides multiple benefits in evolving glucose-limited populations of Escherichia coli",

abstract = "Beneficial mutations in diversifying glucose-limited Escherichia coli populations are mostly unidentified. The genome of an evolved isolate with multiple differences from that of the ancestor was fully assembled. Remarkably, a single mutation in hfq was responsible for the multiple benefits under glucose limitation through changes in at least five regulation targets.",

keywords = "Adaptation, Physiological, Escherichia coli/genetics, Escherichia coli Proteins/genetics, Evolution, Molecular, Gene Expression Regulation, Bacterial, Genome, Bacterial, Glucose/metabolism, Host Factor 1 Protein/genetics, Mutation",

author = "Ram Maharjan and Zhemin Zhou and Yan Ren and Yang Li and Jo{\"e}l Gaff{\'e} and Dominique Schneider and Christopher McKenzie and Reeves, {Peter R.} and Thomas Ferenci and Lei Wang",

year = "2010",

month = sep,

doi = "10.1128/JB.00368-10",

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AU - Maharjan, Ram

AU - Zhou, Zhemin

AU - Ren, Yan

AU - Li, Yang

AU - Gaffé, Joël

AU - Schneider, Dominique

AU - McKenzie, Christopher

AU - Reeves, Peter R.

AU - Ferenci, Thomas

AU - Wang, Lei

PY - 2010/9

Y1 - 2010/9

N2 - Beneficial mutations in diversifying glucose-limited Escherichia coli populations are mostly unidentified. The genome of an evolved isolate with multiple differences from that of the ancestor was fully assembled. Remarkably, a single mutation in hfq was responsible for the multiple benefits under glucose limitation through changes in at least five regulation targets.

AB - Beneficial mutations in diversifying glucose-limited Escherichia coli populations are mostly unidentified. The genome of an evolved isolate with multiple differences from that of the ancestor was fully assembled. Remarkably, a single mutation in hfq was responsible for the multiple benefits under glucose limitation through changes in at least five regulation targets.

KW - Adaptation, Physiological

KW - Escherichia coli/genetics

KW - Escherichia coli Proteins/genetics

KW - Evolution, Molecular

KW - Gene Expression Regulation, Bacterial

KW - Genome, Bacterial

KW - Glucose/metabolism

KW - Host Factor 1 Protein/genetics

KW - Mutation

U2 - 10.1128/JB.00368-10

DO - 10.1128/JB.00368-10

M3 - Article

C2 - 20543067

SN - 0021-9193

VL - 192

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EP - 4521

JO - Journal of Bacteriology

JF - Journal of Bacteriology

IS - 17

ER -

Genomic identification of a novel mutation in hfq that provides multiple benefits in evolving glucose-limited populations of Escherichia coli

Abstract

Keywords

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