Genomic identification of a novel mutation in hfq that provides multiple benefits in evolving glucose-limited populations of Escherichia coli

Ram Maharjan, Zhemin Zhou, Yan Ren, Yang Li, Joël Gaffé, Dominique Schneider, Christopher McKenzie, Peter R. Reeves, Thomas Ferenci, Lei Wang

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

Beneficial mutations in diversifying glucose-limited Escherichia coli populations are mostly unidentified. The genome of an evolved isolate with multiple differences from that of the ancestor was fully assembled. Remarkably, a single mutation in hfq was responsible for the multiple benefits under glucose limitation through changes in at least five regulation targets.

Original languageEnglish
Pages (from-to)4517-4521
Number of pages5
JournalJournal of Bacteriology
Volume192
Issue number17
DOIs
Publication statusPublished - Sep 2010
Externally publishedYes

Keywords

  • Adaptation, Physiological
  • Escherichia coli/genetics
  • Escherichia coli Proteins/genetics
  • Evolution, Molecular
  • Gene Expression Regulation, Bacterial
  • Genome, Bacterial
  • Glucose/metabolism
  • Host Factor 1 Protein/genetics
  • Mutation

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