Ghrelin: A GH-releasing, appetite-regulating gastric hormone

Joseph Di Michele, Fabio Rotondo, Kalman Kovacs*, Antonio Di Ieva, Luis V. Syro, Eleanor Latta, Michael D. Cusimano

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Ghrelin is a hormone that stimulates growth hormone (GH) release, and regulates appetite and feeding habits. It is synthesized and expressed to varying degrees in several organs and neoplasms. Its presence has been reported in the gastrointestinal and respiratory tracts, endocrine organs, cardiovascular system, kidney and central nervous system. Ghrelin producing cells can be demonstrated in the stomach, intestines, pancreas, kidneys, brain, and pituitary. The present review summarizes findings regarding the function and regulation of ghrelin in different organs and in various diseases.

Original languageEnglish
Pages (from-to)51-65
Number of pages15
JournalAdvances in Neuroimmune Biology
Issue number2
Publication statusPublished - 2013
Externally publishedYes


  • Growth hormone
  • orphan receptor
  • stomach


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